Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume

Details

• Alternative Title:
  Part Fibre Toxicol
• Personal Author:
  Zeidler-Erdely, Patti C ; Kashon, Michael L ; Battelli, Lori A ; Young, Shih-Houng ; Erdely, Aaron ; Roberts, Jenny R ; Reynolds, Steven H ; Antonini, James M
• Description:
  Background
  
  Welding fume has been categorized as "possibly carcinogenic" to humans. Our objectives were to characterize the lung response to carcinogenic and non-carcinogenic metal-containing welding fumes and to determine if these fumes caused increased lung tumorigenicity in A/J mice, a lung tumor susceptible strain. We exposed male A/J and C57BL/6J, a lung tumor resistant strain, by pharyngeal aspiration four times (once every 3 days) to 85 μg of gas metal arc-mild steel (GMA-MS), GMA-stainless steel (SS), or manual metal arc-SS (MMA-SS) fume, or to 25.5 μg soluble hexavalent chromium (S-Cr). Shams were exposed to saline vehicle. Bronchoalveolar lavage (BAL) was done at 2, 7, and 28 days post-exposure. For the lung tumor study, gross tumor counts and histopathological changes were assessed in A/J mice at 48 and 78 weeks post-exposure.
  
  Results
  
  BAL revealed notable strain-dependent differences with regards to the degree and resolution of the inflammatory response after exposure to the fumes. At 48 weeks, carcinogenic metal-containing GMA-SS fume caused the greatest increase in tumor multiplicity and incidence, but this was not different from sham. By 78 weeks, tumor incidence in the GMA-SS group versus sham approached significance (p = 0.057). A significant increase in perivascular/peribronchial lymphoid infiltrates for the GMA-SS group versus sham and an increased persistence of this fume in lung cells compared to the other welding fumes was found.
  
  Conclusion
  
  The increased persistence of GMA-SS fume in combination with its metal composition may trigger a chronic, but mild, inflammatory state in the lung possibly enhancing tumorigenesis in this susceptible mouse strain.
  
  
• Subjects:
  Research
• Source:
  Part Fibre Toxicol. 2008; 5:12.
• Document Type:
  Journal Article
• Volume:
  5
• NIOSHTIC Number:
  nn:20034568
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:57c562f1e3a8c1131c3cebdf1fbe6a1d63bea2dc3b6d3db7dd77931faa46657b0d5b7a1c1296880a59acf6c9240713397193871a99952d0f5097f4a6f83214c9
• Download URL:
  https://stacks.cdc.gov/view/cdc/3649/cdc_3649_DS1.pdf
• File Type:
  [PDF - 1.88 MB ]