Pulmonary inflammatory effects of source-oriented particulate matter from California’s San Joaquin Valley

Plummer, Laurel E.; Carosino, Christopher M.; Bein, Keith J.; Zhao, Yongjing; Willits, Neil; Smiley-Jewell, Suzette; Wexler, Anthony S.; Pinkerton, Kent E.

doi:10.1016/j.atmosenv.2015.08.043

i

Pulmonary inflammatory effects of source-oriented particulate matter from California’s San Joaquin Valley

Supporting Files

Oct 1 2015
By Plummer, Laurel E. ; Carosino, Christopher M. ; Bein, Keith J. ; ...

Details

Alternative Title:

Atmos Environ (1994)
Personal Author:

Plummer, Laurel E. ; Carosino, Christopher M. ; Bein, Keith J. ; Zhao, Yongjing ; Willits, Neil ; Smiley-Jewell, Suzette ; Wexler, Anthony S. ; Pinkerton, Kent E.
Description:

The EPA regulates ambient particulate matter (PM) because substantial associations have been established between PM and health impacts. Presently, regulatory compliance involves broad control of PM emission sources based on mass concentration rather than chemical composition, although PM toxicity is likely to vary depending upon PM physicochemical properties. The overall objective of this study was to help inform source-specific PM emission control regulations. For the first time, source-oriented PM was collected from the atmosphere in Fresno, CA, onto 38 source/size substrates. Mice were exposed via oropharyngeal aspiration to equivalent mass doses [50 μg] of two size fractions: ultrafine (Dp < 0.17μm) and submicron fine (0.17 < Dp < 1 μm) during summer and winter seasons. At 24 hours post-exposure, cellular and biochemical indicators of pulmonary inflammation were evaluated in the bronchoalveolar lavage fluid. Significant inflammatory responses were elicited by vehicle, regional background, and cooking PM sources that were dependent on season and particle size. This is the first study of source-oriented toxicity of atmospheric PM and supports source-specific emissions control strategies.
Subjects:

Air Pollution Article Fresno PM Submicron Fine Ultrafine
Source:

Atmos Environ (1994). 119:174-181.
Pubmed ID:

26568698
Pubmed Central ID:

PMC4639935
Document Type:

Journal Article
Funding:

P30 ES023513/ES/NIEHS NIH HHS/United States ; U50 OH007550/OH/NIOSH CDC HHS/United States ; U54 OH007550/OH/NIOSH CDC HHS/United States
Volume:

119
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:2726bdda19687c29551edf7eb30550b1d161b8b6342377431d7d25cd92b45afe
Download URL:

https://stacks.cdc.gov/view/cdc/36448/cdc_36448_DS1.pdf
File Type:

[PDF - 1.20 MB ]

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