Human Brucella canis Infection and Subsequent Laboratory Exposures Associated with a Puppy, New York City, 2012

Details

• Alternative Title:
  Zoonoses Public Health
• Personal Author:
  Dentinger, Catherine M. ; Jacob, Kathleen ; Lee, Lillian V. ; Mendez, Herman A. ; Chotikanatis, Kobkul ; McDonough, Patrick L. ; Chico, David M. ; De, Barun K. ; Traxler, Rita M. ; Campagnolo, Enzo R. ; Schmitt, David ; Guerra, Marta A. ; Slavinski, Sally A.
• Description:
  Human Brucella canis infection incidence is unknown. Most identified cases are associated with pet dogs. Laboratory-acquired infections can occur following contact with Brucella spp. We identified a paediatric B. canis case, the source and other exposed persons. A 3-year-old New York City child with fever and dyspnoea was hospitalized for 48 h for bronchiolitis. After her admission, blood culture grew B. canis, she was prescribed anti-microbials and recovered. B. canis was also isolated from blood of the child's pet dog; these isolates were genetically similar. The dog originated from an Iowa breeding facility which was quarantined after identification of the dog's infection. Additionally, 31 laboratory workers were exposed and subsequently monitored for symptoms; 15 completed post-exposure prophylaxis. To our knowledge, this is the first report strongly suggesting B. canis zoonotic transmission to a child in the United States, and highlights the need for coordinated control policies to minimize human illness.
• Subjects:
  Animals Anti-Bacterial Agents Article Brucella Canis Brucellosis Child, Preschool Commerce Dog Diseases Dogs Female Humans Iowa New York City Pennsylvania Pet Dogs Trimethoprim, Sulfamethoxazole Drug Combination Zoonoses Zoonosis

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• Source:
  Zoonoses Public Health. 62(5):407-414.
• Pubmed ID:
  25363807
• Pubmed Central ID:
  PMC4639931
• Document Type:
  Journal Article
• Funding:
  5U90TP000546/TP/OPHPR CDC HHS/United States ; CC999999/Intramural CDC HHS/United States
• Volume:
  62
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:350b2ca483988e57d6b5f4b38df029423c0aada2149e4b2b4af7a70dd48ce651
• Download URL:
  https://stacks.cdc.gov/view/cdc/36446/cdc_36446_DS1.pdf
• File Type:
  [PDF - 345.67 KB ]