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Successful Treatment of an Adolescent with Naegleria fowleri Primary Amebic Meningoencephalitis
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  1. Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of One Fatal and One Surviving Case
    Personal Author:
    Cope, Jennifer R.; Conrad, Dennis A.; Cohen, Naiomi; Cotilla, Manuel; DaSilva, Alexandre; Jackson, Jonathan; Visvesvara, Govinda;
    Published:
    Dec 17 2015
    Source:
    Clin Infect Dis. 62(6):774-776.
    Description:
    Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fa...
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  2. Primary Amebic Meningoencephalitis: What Have We Learned in the Last Five Years?
    Personal Author:
    Cope, Jennifer R.; Ali, Ibne K.;
    Published:
    Sep 2016
    Source:
    Curr Infect Dis Rep. 18(10):31.
    Description:
    Primary amebic meningoencephalitis (PAM) is a devastating infection of the brain caused by the thermophilic free-living ameba, Naegleria fowleri. Infection can occur when water containing the ameba enters the body through the nose, usually during rec...
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  3. Risk for Transmission of Naegleria fowleri from Solid Organ Transplantation
    Personal Author:
    Roy, SL; Metzger, R; Chen, JG; Laham, FR; Martin, M; Kipper, SW; Smith, LE; Lyon, GM; Haffner, J; Ross, JE; Rye, AK; Johnson, W; Bodager, D; Friedman, M; Walsh, DJ; Collins, C; Inman, B; Davis, BJ; Robinson, T; Paddock, C; Zaki, Sherif R.; Kuehnert, Matthew J.; DaSilva, A; Qvarnstrom, Y; Sriram, R; Visvesvara, GS;
    Published:
    Nov 26 2013
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    Am J Transplant. 14(1):163-171.
    Description:
    Primary amebic meningoencephalitis (PAM) caused by the free-living ameba (FLA) Naegleria fowleri is a rare but rapidly fatal disease of the central nervous system (CNS) affecting predominantly young, previously healthy persons. No effective chemother...
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  4. Primary Amebic Meningoencephalitis Caused by Naegleria fowleri, Karachi, Pakistan
    Personal Author:
    Shakoor, Sadia; Beg, Mohammad Asim; Mahmood, Syed Faisal; Bandea, Rebecca; Sriram, Rama; Noman, Fatima; Ali, Farheen; Visvesvara, Govinda S.; Zafar, Afia;
    Published:
    Feb 2011
    Source:
    Emerg Infect Dis. 17(2):258-261.
    Description:
    We report 13 cases of Naegleria fowleri primary amebic meningoencephalitis in persons in Karachi, Pakistan, who had no history of aquatic activities. Infection likely occurred through ablution with tap water. An increase in primary amebic meningoence...
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  5. Primary Amebic Meningoencephalitis Associated with Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation
    Personal Author:
    Cope, Jennifer R.; Murphy, Jennifer; Kahler, Amy; Gorbett, Daniel G.; Ali, Ibne; Taylor, Brandi; Corbitt, Lisa; Roy, Shantanu; Lee, Nicole; Roellig, Dawn; Brewer, Scott; Hill, Vincent R.;
    Published:
    Feb 01 2018
    Source:
    Clin Infect Dis. 66(4):548-553
    Description:
    Background : Naegleria fowleri is a thermophilic ameba found in freshwater that causes primary amebic meningoencephalitis (PAM) when it enters the nose and migrates to the brain. Patient exposure to water containing the ameba typically occurs in warm...
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    Filetype[PDF - 384.23 KB]