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Successful Treatment of an Adolescent with Naegleria fowleri Primary Amebic Meningoencephalitis
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  1. Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of One Fatal and One Surviving Case
    Personal Author:
    Cope, Jennifer R.; Conrad, Dennis A.; Cohen, Naiomi; Cotilla, Manuel; DaSilva, Alexandre; Jackson, Jonathan; Visvesvara, Govinda;
    Published Date:
    Dec 17 2015
    Source:
    Clin Infect Dis. 62(6):774-776.
    Description:
    Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fa...
    File Type:
    Filetype[PDF - 73.90 KB]
  2. Primary Amebic Meningoencephalitis: What Have We Learned in the Last Five Years?
    Personal Author:
    Cope, Jennifer R.; Ali, Ibne K.;
    Published Date:
    Sep 2016
    Source:
    Curr Infect Dis Rep. 18(10):31.
    Description:
    Primary amebic meningoencephalitis (PAM) is a devastating infection of the brain caused by the thermophilic free-living ameba, Naegleria fowleri. Infection can occur when water containing the ameba enters the body through the nose, usually during rec...
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    Filetype[PDF - 126.75 KB]
  3. Risk for Transmission of Naegleria fowleri from Solid Organ Transplantation
    Personal Author:
    Roy, SL; Metzger, R; Chen, JG; Laham, FR; Martin, M; Kipper, SW; Smith, LE; Lyon, GM; Haffner, J; Ross, JE; Rye, AK; Johnson, W; Bodager, D; Friedman, M; Walsh, DJ; Collins, C; Inman, B; Davis, BJ; Robinson, T; Paddock, C; Zaki, Sherif R.; Kuehnert, Matthew J.; DaSilva, A; Qvarnstrom, Y; Sriram, R; Visvesvara, GS;
    Published Date:
    Nov 26 2013
    Source:
    Am J Transplant. 14(1):163-171.
    Description:
    Primary amebic meningoencephalitis (PAM) caused by the free-living ameba (FLA) Naegleria fowleri is a rare but rapidly fatal disease of the central nervous system (CNS) affecting predominantly young, previously healthy persons. No effective chemother...
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    Filetype[PDF - 557.91 KB]
  4. Estimation of Undiagnosed Naegleria fowleri Primary Amebic Meningoencephalitis, United States
    Personal Author:
    Matanock, Almea; Mehal, Jason M.; Liu, Lindy; Blau, Diana M.; Cope, Jennifer R.;
    Published Date:
    Jan 2018
    Source:
    Emerg Infect Dis. 24(1):162-164.
    Description:
    Primary amebic meningoencephalitis is an acute, rare, typically fatal disease. We used epidemiologic risk factors and multiple cause-of-death mortality data to estimate the number of deaths that fit the typical pattern for primary amebic meningoencep...
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  5. Primary Amebic Meningoencephalitis Associated with Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation
    Personal Author:
    Cope, Jennifer R.; Murphy, Jennifer; Kahler, Amy; Gorbett, Daniel G.; Ali, Ibne; Taylor, Brandi; Corbitt, Lisa; Roy, Shantanu; Lee, Nicole; Roellig, Dawn; Brewer, Scott; Hill, Vincent R.;
    Published Date:
    Feb 01 2018
    Source:
    Clin Infect Dis. 66(4):548-553
    Description:
    BackgroundNaegleria fowleri is a thermophilic ameba found in freshwater that causes primary amebic meningoencephalitis (PAM) when it enters the nose and migrates to the brain. Patient exposure to water containing the ameba typically occurs in warm fr...
    File Type:
    Filetype[PDF - 384.23 KB]