Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of One Fatal and One Surviving Case

Details

• Alternative Title:
  Clin Infect Dis
• Personal Author:
  Cope, Jennifer R. ; Conrad, Dennis A. ; Cohen, Naiomi ; Cotilla, Manuel ; DaSilva, Alexandre ; Jackson, Jonathan ; Visvesvara, Govinda
• Description:
  Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.
• Subjects:
  Antiprotozoal Agents Central Nervous System Protozoal Infections Child Fatal Outcome Humans Male Naegleria Fowleri Phosphorylcholine Treatment Outcome
• Keywords:
  Miltefosine Primary Amebic Meningoencephalitis
• Source:
  Clin Infect Dis. 62(6):774-776
• Pubmed ID:
  26679626
• Pubmed Central ID:
  PMC4775347
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  62
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:734ac33c44844c0aa69a6fbe8e79b02c503a1359f69cd888c87a98d83323049b59217b79c598fa4f16f857a193f0958b1e25b2f70ce29f1cc320f7467351a0fc
• Download URL:
  https://stacks.cdc.gov/view/cdc/38329/cdc_38329_DS1.pdf
• File Type:
  [PDF - 73.90 KB ]