Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of One Fatal and One Surviving Case

Cope, Jennifer R.; Conrad, Dennis A.; Cohen, Naiomi; Cotilla, Manuel; DaSilva, Alexandre; Jackson, Jonathan; Visvesvara, Govinda

doi:10.1093/cid/civ1021

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of One Fatal and One Surviving Case

3 15 2016
By Cope, Jennifer R. ; Conrad, Dennis A. ; Cohen, Naiomi ; ...
http://dx.doi.org/10.1093/cid/civ1021
Source: Clin Infect Dis. 62(6):774-776

[PDF-73.90 KB]

English

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Details:

Alternative Title:

Clin Infect Dis
Personal Author:

Cope, Jennifer R. ; Conrad, Dennis A. ; Cohen, Naiomi ; Cotilla, Manuel ; DaSilva, Alexandre ; ... More +

Cope, Jennifer R. ; Conrad, Dennis A. ; Cohen, Naiomi ; Cotilla, Manuel ; DaSilva, Alexandre ; Jackson, Jonathan ; Visvesvara, Govinda Less -
Description:

Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.
Subjects:

[+]

Antiprotozoal Agents Central Nervous System Protozoal Infections Child Fatal Outcome Humans Male Naegleria Fowleri Phosphorylcholine Treatment Outcome
Keywords:

[+]

Miltefosine Primary Amebic Meningoencephalitis
Source:

Clin Infect Dis. 62(6):774-776
Pubmed ID:

26679626
Pubmed Central ID:

PMC4775347
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/
Volume:

62
Issue:

6
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:cf859fdb5e9e043f8528b4293c197722fa6b79004b195579d985b6e7eca3572b
Download URL:

https://stacks.cdc.gov/view/cdc/38329/cdc_38329_DS1.pdf
File Type:

nihms753758.nxml

xml

More +