Details:

Alternative Title:
Neuron
Publisher's site:
http://dx.doi.org/10.1016/j.neuron.2015.07.025
Personal Author:
Clowney, E. Josephine ; Iguchi, Shinya ; Bussell, Jennifer J. ; Scheer, Elias ; Ruta, Vanessa
Clowney, E. Josephine ; Iguchi, Shinya ; Bussell, Jennifer J. ; Scheer, Elias ; Ruta, Vanessa Less -
Description:
Throughout the animal kingdom, internal states generate long-lasting and self-perpetuating chains of behavior. In Drosophila, males instinctively pursue females with a lengthy and elaborate courtship ritual triggered by activation of sexually dimorphic P1 interneurons. Gustatory pheromones are thought to activate P1 neurons but the circuit mechanisms that dictate their sensory responses to gate entry into courtship remain unknown. Here, we use circuit mapping and in vivo functional imaging techniques to trace gustatory and olfactory pheromone circuits to their point of convergence onto P1 neurons and reveal how their combined input underlies selective tuning to appropriate sexual partners. We identify inhibition, even in response to courtship-promoting pheromones, as a key circuit element that tunes and tempers P1 neuron activity. Our results suggest a circuit mechanism in which balanced excitation and inhibition underlie discrimination of prospective mates and stringently regulate the transition to courtship in Drosophila.
Subjects:
[+]
Acetylcholine Analysis Of Variance Animals Animals, Genetically Modified Arthropod Antennae Article Central Nervous System Chemoreceptor Cells Courtship Drosophila Drosophila Proteins Female Green Fluorescent Proteins Male Nerve Net Optogenetics Pheromones Taste Transcription Factors Xanthenes
Source:
Neuron. 87(5):1036-1049.
Pubmed ID:
26279475
Pubmed Central ID:
PMC4560615
Document Type:
Journal Article
Funding:
DP2 NS087942/NS/NINDS NIH HHS/United States ; DP2 NS0879422013/DP/NCCDPHP CDC HHS/United States
DP2 NS087942/NS/NINDS NIH HHS/United States ; DP2 NS0879422013/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:44d020ca2047efe3fc292d9d262f1f013026c82f71c9ced473766cf92760b33b
Download URL:
https://stacks.cdc.gov/view/cdc/36270/cdc_36270_DS1.pdf
File Type:

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