Multimodal chemosensory circuits controlling male courtship in Drosophila

Details

• Alternative Title:
  Neuron
• Personal Author:
  Clowney, E. Josephine ; Iguchi, Shinya ; Bussell, Jennifer J. ; Scheer, Elias ; Ruta, Vanessa
• Description:
  Throughout the animal kingdom, internal states generate long-lasting and self-perpetuating chains of behavior. In Drosophila, males instinctively pursue females with a lengthy and elaborate courtship ritual triggered by activation of sexually dimorphic P1 interneurons. Gustatory pheromones are thought to activate P1 neurons but the circuit mechanisms that dictate their sensory responses to gate entry into courtship remain unknown. Here, we use circuit mapping and in vivo functional imaging techniques to trace gustatory and olfactory pheromone circuits to their point of convergence onto P1 neurons and reveal how their combined input underlies selective tuning to appropriate sexual partners. We identify inhibition, even in response to courtship-promoting pheromones, as a key circuit element that tunes and tempers P1 neuron activity. Our results suggest a circuit mechanism in which balanced excitation and inhibition underlie discrimination of prospective mates and stringently regulate the transition to courtship in Drosophila.
• Subjects:
  Acetylcholine Analysis Of Variance Animals Animals, Genetically Modified Arthropod Antennae Article Central Nervous System Chemoreceptor Cells Courtship Drosophila Drosophila Proteins Female Green Fluorescent Proteins Male Nerve Net Optogenetics Pheromones Taste Transcription Factors Xanthenes

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• Source:
  Neuron. 87(5):1036-1049.
• Pubmed ID:
  26279475
• Pubmed Central ID:
  PMC4560615
• Document Type:
  Journal Article
• Funding:
  DP2 NS087942/NS/NINDS NIH HHS/United States ; DP2 NS0879422013/DP/NCCDPHP CDC HHS/United States
• Volume:
  87
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:44d020ca2047efe3fc292d9d262f1f013026c82f71c9ced473766cf92760b33b
• Download URL:
  https://stacks.cdc.gov/view/cdc/36270/cdc_36270_DS1.pdf
• File Type:
  [PDF - 2.93 MB ]