Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries

Details

• Alternative Title:
  Eur Respir J
• Personal Author:
  Getahun, Haileyesus ; Matteelli, Alberto ; Abubakar, Ibrahim ; Aziz, Mohamed Abdel ; Baddeley, Annabel ; Barreira, Draurio ; Boon, Saskia Den ; Gutierrez, Susana Marta Borroto ; Bruchfeld, Judith ; Burhan, Erlina ; Cavalcante, Solange ; Cedillos, Rolando ; Chaisson, Richard ; Chee, Cynthia Bin-Eng ; Chesire, Lucy ; Corbett, Elizabeth ; Dara, Masoud ; Denholm, Justin ; de Vries, Gerard ; Falzon, Dennis ; Ford, Nathan ; Gale-Rowe, Margaret ; Gilpin, Chris ; Girardi, Enrico ; Go, Un-Yeong ; Govindasamy, Darshini ; Grant, Alison D. ; Grzemska, Malgorzata ; Harris, Ross ; Horsburgh, C. Robert ; Ismayilov, Asker ; Jaramillo, Ernesto ; Kik, Sandra ; Kranzer, Katharina ; Lienhardt, Christian ; LoBue, Philip ; Lonnroth, Knut ; Marks, Guy ; Menzies, Dick ; Migliori, Giovanni Battista ; Mosca, Davide ; Mukadi, Ya Diul ; Mwinga, Alwyn ; Nelson, Lisa ; Nishikiori, Nobuyuki ; Oordt-Speets, Anouk ; Rangaka, Molebogeng Xheedha ; Reis, Andreas ; Rotz, Lisa ; Sandgren, Andreas ; Schepisi, Monica Sañé ; Schünemann, Holger J. ; Sharma, Surender Kumar ; Sotgiu, Giovanni ; Stagg, Helen R. ; Sterling, Timothy R. ; Tayeb, Tamara ; Uplekar, Mukund ; van der Werf, Marieke J. ; Vandevelde, Wim ; van Kessel, Femke ; van't Hoog, Anna ; Varma, Jay K. ; Vezhnina, Natalia ; Voniatis, Constantia ; Vonk Noordegraaf-Schouten, Marije ; Weil, Diana ; Weyer, Karin ; Wilkinson, Robert John ; Yoshiyama, Takashi ; Zellweger, Jean Pierre ; Raviglione, Mario
• Description:
  Latent tuberculosis infection (LTBI) is characterised by the presence of immune responses to previously acquired Mycobacterium tuberculosis infection without clinical evidence of active tuberculosis (TB). Here we report evidence-based guidelines from the World Health Organization for a public health approach to the management of LTBI in high risk individuals in countries with high or middle upper income and TB incidence of <100 per 100 000 per year. The guidelines strongly recommend systematic testing and treatment of LTBI in people living with HIV, adult and child contacts of pulmonary TB cases, patients initiating anti-tumour necrosis factor treatment, patients receiving dialysis, patients preparing for organ or haematological transplantation, and patients with silicosis. In prisoners, healthcare workers, immigrants from high TB burden countries, homeless persons and illicit drug users, systematic testing and treatment of LTBI is conditionally recommended, according to TB epidemiology and resource availability. Either commercial interferon-gamma release assays or Mantoux tuberculin skin testing could be used to test for LTBI. Chest radiography should be performed before LTBI treatment to rule out active TB disease. Recommended treatment regimens for LTBI include: 6 or 9 month isoniazid; 12 week rifapentine plus isoniazid; 3-4 month isoniazid plus rifampicin; or 3-4 month rifampicin alone.
• Subjects:
  Antirheumatic Agents Antitubercular Agents Article Coinfection Comorbidity Disease Management Drug Users Emigrants And Immigrants Evidence-Based Medicine Health Personnel HIV Infections Humans Ill-Housed Persons Interferon-gamma Release Tests Isoniazid Kidney Failure, Chronic Latent Tuberculosis Mass Screening Practice Guidelines As Topic Prisoners Public Health Radiography, Thoracic Renal Dialysis Rifampin Risk Assessment Silicosis Substance-Related Disorders Transplant Recipients Tuberculin Test Tumor Necrosis Factor-alpha World Health Organization

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• Source:
  Eur Respir J. 46(6):1563-1576
• Pubmed ID:
  26405286
• Pubmed Central ID:
  PMC4664608
• Document Type:
  Journal Article
• Funding:
  SRF-2011-04-001/DH_/Department of HealthUnited Kingdom/ ; 091769/Wellcome TrustUnited Kingdom/ ; P30 AI094189/AI/NIAID NIH HHSUnited States/ ; 104803/Wellcome TrustUnited Kingdom/ ; CC999999/Intramural CDC HHSUnited States/
• Volume:
  46
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c5ab6cf428d267874f35a4c59cb8c2c0bde1c89546b0ac526e1e94546bb1f069
• Download URL:
  https://stacks.cdc.gov/view/cdc/36247/cdc_36247_DS1.pdf
• File Type:
  [PDF - 405.01 KB ]