An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein

Yoon, Aerin; Yi, Kye Sook; Chang, So Young; Kim, Sung Hwan; Song, Manki; Choi, Jung Ah; Bourgeois, Melissa; Hossain, M. Jaber; Chen, Li-Mei; Donis, Ruben O.; Kim, Hyori; Lee, Yujean; Hwang, Do Been; Min, Ji-Young; Chang, Shin Jae; Chung, Junho

doi:10.1371/journal.pone.0141312

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An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein

Published Date:

Oct 29 2015

Publisher's site:

http://dx.doi.org/10.1371/journal.pone.0141312

Source:

PLoS One. 10(10).

[PDF-1.83 MB]

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Alternative Title:

PLoS One

Personal Author:

Yoon, Aerin ; Yi, Kye Sook ; Chang, So Young ; Kim, Sung Hwan ; Song, Manki ; ... More ▼

Description:

To date, four main mechanisms mediating inhibition of influenza infection by anti-hemagglutinin antibodies have been reported. Anti-globular-head-domain antibodies block either influenza virus receptor binding to the host cell or progeny virion release from the host cell. Anti-stem region antibodies hinder the membrane fusion process or induce antibody-dependent cytotoxicity to infected cells. In this study we identified a human monoclonal IgG1 antibody (CT302), which does not inhibit both the receptor binding and the membrane fusion process but efficiently reduced the nucleus entry of viral nucleoprotein suggesting a novel inhibition mechanism of viral infection by antibody. This antibody binds to the subtype-H3 hemagglutinin globular head domain of group-2 influenza viruses circulating throughout the population between 1997 and 2007.

Subject:

[+]

Pubmed ID:

26512723

Pubmed Central ID:

PMC4626144

Document Type:

Journal Article

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CDC Public Access

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An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein

An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein

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