Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0141312
Personal Author:
Yoon, Aerin ; Yi, Kye Sook ; Chang, So Young ; Kim, Sung Hwan ; Song, Manki ; ... More +
Yoon, Aerin ; Yi, Kye Sook ; Chang, So Young ; Kim, Sung Hwan ; Song, Manki ; Choi, Jung Ah ; Bourgeois, Melissa ; Hossain, M. Jaber ; Chen, Li-Mei ; Donis, Ruben O. ; Kim, Hyori ; Lee, Yujean ; Hwang, Do Been ; Min, Ji-Young ; Chang, Shin Jae ; Chung, Junho Less -
Description:
To date, four main mechanisms mediating inhibition of influenza infection by anti-hemagglutinin antibodies have been reported. Anti-globular-head-domain antibodies block either influenza virus receptor binding to the host cell or progeny virion release from the host cell. Anti-stem region antibodies hinder the membrane fusion process or induce antibody-dependent cytotoxicity to infected cells. In this study we identified a human monoclonal IgG1 antibody (CT302), which does not inhibit both the receptor binding and the membrane fusion process but efficiently reduced the nucleus entry of viral nucleoprotein suggesting a novel inhibition mechanism of viral infection by antibody. This antibody binds to the subtype-H3 hemagglutinin globular head domain of group-2 influenza viruses circulating throughout the population between 1997 and 2007.
Subject:
[+]
Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibodies, Neutralizing
Antibodies, Viral
Antibody Affinity
Cell Line
Disease Models, Animal
Epitope Mapping
Epitopes
Ferrets
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Immunoglobulin G
Influenza, Human
Influenza A Virus, H3N2 Subtype
Male
Mice
Models, Molecular
Molecular Sequence Data
Neutralization Tests
Nucleoproteins
Orthomyxoviridae
Orthomyxoviridae Infections
Protein Binding
Protein Conformation
Research Article
Sequence Alignment
Virus Replication

Source:
PLoS One. 10(10)
Pubmed ID:
26512723
Pubmed Central ID:
PMC4626144
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b7a3de15e7ee177919666f93881b9cf7b778c188c58049d4147cd98d4e872d8a
File Type:

Supporting Files

• 	pone.0141312.g005.gif	gif
  	pone.0141312.g005.jpg	jpeg
  	pone.0141312.nxml	xml
  	pone.0141312.s001.docx	docx
  	pone.0141312.t001.gif	gif
  	pone.0141312.t001.jpg	jpeg
  	pone.0141312.t002.gif	gif
  	pone.0141312.t002.jpg	jpeg
  	pone.0141312.g001.gif	gif
  	pone.0141312.g001.jpg	jpeg
  	pone.0141312.g002.gif	gif
  	pone.0141312.g002.jpg	jpeg
  	pone.0141312.g003.gif	gif
  	pone.0141312.g003.jpg	jpeg
  	pone.0141312.g004.gif	gif
  	pone.0141312.g004.jpg	jpeg

More +