Viral and bacterial etiology of severe acute respiratory illness among children < 5 years of age without influenza in Niger

Details

• Alternative Title:
  BMC Infect Dis
• Personal Author:
  Lagare, Adamou ; Maïnassara, Halima Boubacar ; Issaka, Bassira ; Sidiki, Ali ; Tempia, Stefano
• Description:
  Background
  
  Globally, pneumonia is the leading cause of morbidity and mortality in children, with the highest burden experienced in sub-Saharan Africa and Asia. However, there is a dearth of information on the etiology of severe acute respiratory illness (SARI) in Africa, including Niger.
  
  Methods
  
  We implemented a retrospective study as part of national influenza sentinel surveillance in Niger. We randomly selected a sample of nasopharyngeal specimens collected from children <5 years of age hospitalized with SARI from January 2010 through December 2012 in Niger. The samples were selected from individuals that tested negative by real-time reverse transcription polymerase chain reaction (rRT-PCR) for influenza A and B virus. The samples were analyzed using the Fast Track Diagnostic Respiratory Pathogens 21plus Kit (BioMérieux, Luxemburg), which detects 23 respiratory pathogens including 18 viral and 5 bacterial agents.
  
  Results
  
  Among the 160 samples tested, 138 (86 %) tested positive for at least one viral or bacterial pathogen; in 22 (16 %) sample, only one pathogen was detected. We detected at least one respiratory virus in 126 (78 %) samples and at least one bacterium in 102 (64 %) samples. Respiratory syncytial virus (56/160; 35 %), rhinovirus (47/160; 29 %) and parainfluenza virus (39/160; 24 %) were the most common viral pathogens detected. Among bacterial pathogens, Streptococcus pneumoniae (90/160; 56 %) and Haemophilus influenzae type b (20/160; 12 %) predominated.
  
  Conclusions
  
  The high prevalence of certain viral and bacterial pathogens among children <5 years of age with SARI highlights the need for continued and expanded surveillance in Niger.
  
  
• Subjects:
  Bacteria Etiology Niger Research Article Severe Acute Respiratory Illness Virus
• Source:
  BMC Infect Dis. 15.
• Pubmed ID:
  26567015
• Pubmed Central ID:
  PMC4644278
• Document Type:
  Journal Article
• Volume:
  15
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4282216758b6d2049eeba2779ec45cb2e296c99f19c4ccf550d96276acf5e903
• Download URL:
  https://stacks.cdc.gov/view/cdc/35765/cdc_35765_DS1.pdf
• File Type:
  [PDF - 557.75 KB ]