Ebola Virus Outbreak Investigation, Sierra Leone, September 28–November 11, 2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lu, Hui-Jun ; Qian, Jun ; Kargbo, David ; Zhang, Xiao-Guang ; Yang, Fan ; Hu, Yi ; Sun, Yang ; Cao, Yu-Xi ; Deng, Yong-Qiang ; Su, Hao-Xiang ; Dafae, Foday ; Sun, Yu ; Wang, Cheng-Yu ; Nie, Wei-Min ; Bai, Chang-Qing ; Xia, Zhi-Ping ; Liu, Kun ; Kargbo, Brima ; Gao, George F. ; Jiang, Jia-Fu
• Description:
  During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts of West Africa. The China Mobile Laboratory Testing Team was dispatched to support response efforts; during September 28-November 11, 2014, they conducted PCR testing on samples from 1,635 suspected EVD patients. Of those patients, 50.4% were positive, of whom 84.6% lived within a 3-km zone along main roads connecting rural towns and densely populated cities. The median time from symptom onset to testing was 5 days. At testing, 75.7% of the confirmed patients had fever, and 94.1% reported at least 1 gastrointestinal symptom; all symptoms, except rash and hemorrhage, were more frequent in confirmed than nonconfirmed patients. Virus loads were significantly higher in EVD patients with fever, diarrhea, fatigue, or headache. The case-fatality rate was lower among patients 15-44 years of age and with virus loads of <100,000 RNA copies/mL. These findings are key for optimizing EVD control and treatment measures.
• Subjects:
  Adolescent Adult Child Child, Preschool Disease Outbreaks Ebolavirus Female Hemorrhagic Fever, Ebola Humans Infant Male Middle Aged Young Adult

  More +
• Source:
  Emerg Infect Dis. 21(11):1921-1927
• Pubmed ID:
  26485317
• Pubmed Central ID:
  PMC4622249
• Document Type:
  Journal Article
• Place as Subject:
  Africa, Western ; Sierra Leone
• Volume:
  21
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ed7650cdce7e3d6585eb1b2615e658035c79b0cfeaf98bb13d90587bdcc9c0b1
• Download URL:
  https://stacks.cdc.gov/view/cdc/35544/cdc_35544_DS1.pdf
• File Type:
  [PDF - 1.45 MB ]