Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Ubukata, Kimiko ; Chiba, Naoko ; Hanada, Shigeo ; Morozumi, Miyuki ; Wajima, Takeaki ; ... More +
Ubukata, Kimiko ; Chiba, Naoko ; Hanada, Shigeo ; Morozumi, Miyuki ; Wajima, Takeaki ; Shouji, Michi ; Iwata, Satoshi Less -
Corporate Authors:
Invasive Pneumococcal Diseases Surveillance Study Group
Description:
After 7-valent pneumococcal conjugate vaccine (PCV) for children was introduced in Japan in November 2010, we examined changes in Streptococcus pneumoniae serotypes and in genetic antimicrobial drug resistance of isolates from adults with invasive pneumococcal diseases. During April 2010-March 2013, a total of 715 isolates were collected from adults with invasive pneumococcal diseases. Seven-valent PCV serotypes in adults decreased from 43.3% to 23.8%, most noticeably for serotype 6B. Concomitantly, 23-valent pneumococcal polysaccharide vaccine (PPSV23) serotypes decreased from 82.2% to 72.2%; non-PPSV23 serotypes increased from 13.8% to 25.1%. Parallel with serotype changes, genotypic penicillin-resistant S. pneumoniae decreased from 32.4% to 21.1%, and 6 non-PPSV23 serotypes emerged (6D, 15A, 15C, 16F, 23A, and 35B). Respective vaccine coverage rates for 13-valent PCV and PPSV23 differed by disease: 73.9% and 84.3% for patients with pneumonia, 56.4% and 69.2% for patients with bacteremia and sepsis, and 45.7% and 69.3% for patients with meningitis.
Subjects:
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Adult Aged Aged, 80 And Over Anti-Bacterial Agents Antimicrobial Resistance Bacteria Drug Resistance Drug Resistance, Microbial Humans Invasive Pneumococcal Diseases Middle Aged MLST PCV7 PCV13 Pneumococcal Infections Pneumococcal Vaccines PPSV23 Research Respiratory Infections Serogroup Serotype Changes And Drug Resistance In Invasive Pneumococcal Diseases In Adults After Vaccinations In Children, Japan, 2010–2013 Serotypes Streptococci Vaccines
Source:
Emerg Infect Dis. 21(11):1956-1965
Pubmed ID:
26485679
Pubmed Central ID:
PMC4622236
Document Type:
Journal Article
Place as Subject:
Japan
Location:
Asia
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:1905a02d1482e3c231e7a8f7b55ffe52c6d561ed5084bd7714f1f986b9940b86
Download URL:
https://stacks.cdc.gov/view/cdc/35530/cdc_35530_DS1.pdf
File Type:

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