Neurologic Disorders in Immunocompetent Patients with Autochthonous Acute Hepatitis E

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• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Perrin, H. Blasco ; Cintas, P. ; Abravanel, F. ; Gérolami, R. ; d'Alteroche, L. ; Raynal, J.-N. ; Alric, L. ; Dupuis, E. ; Prudhomme, L. ; Vaucher, E. ; Couzigou, P. ; Liversain, J.-M. ; Bureau, C. ; Vinel, J.-P. ; Kamar, N. ; Izopet, J. ; Peron, J.-M.
• Description:
  Neurologic disorders, mainly Guillain-Barré syndrome and Parsonage–Turner syndrome (PTS), have been described in patients with hepatitis E virus (HEV) infection in industrialized and developing countries. We report a wider range of neurologic disorders in nonimmunocompromised patients with acute HEV infection. Data from 15 French immunocompetent patients with acute HEV infection and neurologic disorders were retrospectively recorded from January 2006 through June 2013. The disorders could be divided into 4 main entities: mononeuritis multiplex, PTS, meningoradiculitis, and acute demyelinating neuropathy. HEV infection was treated with ribavirin in 3 patients (for PTS or mononeuritis multiplex). One patient was treated with corticosteroids (for mononeuropathy multiplex), and 5 others received intravenous immunoglobulin (for PTS, meningoradiculitis, Guillain-Barré syndrome, or Miller Fisher syndrome). We conclude that pleiotropic neurologic disorders are seen in HEV-infected immunocompetent patients. Patients with acute neurologic manifestations and aminotransferase abnormalities should be screened for HEV infection.
• Subjects:
  Abravanel F Acute Disease Adult Aged Cintas P Demyelinating Neuropathy D’Alteroche L Education, Medical, Continuing Et Al. Neurologic Disorders In Nonimmunocompromised Patients With Autochthonous Acute Hepatitis E. Emerg Infect Dis. 2015 Nov [date Cited]. Http://dx.doi.org/10.3201/eid2111.141789 Female Guillain-Barré Syndrome Gérolami R Hepatitis E Hepatitis E Virus HEV Humans Immunocompetence Immunocompetent Male Meningoradiculitis Middle Aged Mononeuritis Multiplex Nervous System Diseases Neurological Manifestations Neurologic Disorders Neurologic Disorders In Immunocompetent Patients With Autochthonous Acute Hepatitis E Parsonage–Turner Syndrome Raynal JN Suggested Citation For This Article: Blasco Perrin H Synopsis Viruses

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• Source:
  Emerg Infect Dis. 21(11):1928-1934
• Pubmed ID:
  26490255
• Pubmed Central ID:
  PMC4622229
• Document Type:
  Journal Article
• Volume:
  21
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9bd9044ad14e4e5836357d2d79a2489197422e6fa415cf7c59c0f189add84e82
• Download URL:
  https://stacks.cdc.gov/view/cdc/35523/cdc_35523_DS1.pdf
• File Type:
  [PDF - 1.18 MB ]