Epidemiology of acute respiratory infections in children - preliminary results of a cohort in a rural north Indian community

Details

• Alternative Title:
  BMC Infect Dis
• Personal Author:
  Krishnan, Anand ; Amarchand, Ritvik ; Gupta, Vivek ; Lafond, Kathryn E. ; Suliankatchi, Rizwan Abdulkader ; Saha, Siddhartha ; Rai, Sanjay ; Misra, Puneet ; Purakayastha, Debjani Ram ; Wahi, Abhishek ; Sreenivas, Vishnubhatla ; Kapil, Arti ; Dawood, Fatimah ; Pandav, Chandrakant S. ; Broor, Shobha ; Kapoor, Suresh K. ; Lal, Renu ; Widdowson, Marc-Alain
• Description:
  Background
  
  Despite acute respiratory infections being a major cause of death among children in developing countries including India, there is a lack of community-based studies that document its burden and aetiology.
  
  Methods
  
  A dynamic cohort of children aged 0–10 years was established in four villages in a north Indian state of Haryana from August 2012 onwards. Trained health workers conducted weekly home visits to screen children for acute respiratory infection (ARI) defined as one of the following: cough, sore throat, nasal congestion, earache/discharge, or breathing difficulty. Nurses clinically assessed these children to grade disease severity based on standard age-specific guidelines into acute upper or lower respiratory infection (AURI or ALRI) and collected nasal/throat swabs for pathogen testing.
  
  Results
  
  Our first year results show that ARI incidence in 0–10 years of age was 5.9 (5.8–6.0) per child-year with minimal gender difference, the ALRI incidence in the under-five age group was higher among boys (0.43; 0.39–0.49) as compared to girls (0.31; 0.26–0.35) per child year. Boys had 2.4 times higher ARI-related hospitalization rate as compared to girls.
  
  Conclusion
  
  ARI impose a significant burden on the children of this cohort. This study platform aims to provide better evidence for prevention and control of pneumonia in developing countries.
  
  
• Subjects:
  Acute Disease Child Child, Preschool Cohort Studies Female Hospitalization Humans Infant Infant, Newborn Male Pneumonia Respiratory Tract Infections Rural Population

  More +
• Source:
  BMC Infect Dis. 15.
• Pubmed ID:
  26502931
• Pubmed Central ID:
  PMC4624162
• Document Type:
  Journal Article
• Place as Subject:
  India
• Volume:
  15
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a143aec1b50b6cbb5e621ce6b25fd5a9437fd2af3de534b66e51be02f688e2c3
• Download URL:
  https://stacks.cdc.gov/view/cdc/35498/cdc_35498_DS1.pdf
• File Type:
  [PDF - 1.53 MB ]