Details:

Alternative Title:
Clin Infect Dis
Personal Author:
Payne, Daniel C. ; Baggs, James ; Zerr, Danielle M. ; Klein, Nicola P. ; Yih, Katherine ; ... More +
Payne, Daniel C. ; Baggs, James ; Zerr, Danielle M. ; Klein, Nicola P. ; Yih, Katherine ; Glanz, Jason ; Curns, Aaron T. ; Weintraub, Eric ; Parashar, Umesh D. Less -
Description:
Background

Rotavirus illness has been linked to childhood seizures. We investigated whether a protective association exists between receipt of rotavirus vaccine and being hospitalized or visiting the emergency department for seizures in the year after vaccination.

Methods

We retrospectively analyzed a cohort of children born after 28 February 2006 (when rotavirus vaccine was licensed in the United States) and enrolled in the Vaccine Safety Datalink (VSD) through November 2009. Seizure rates from 4 to 55 weeks following last rotavirus vaccination were compared by vaccine exposure status (fully vaccinated and unvaccinated). A time-to-event analysis using a Cox proportional hazards model was performed, accounting for time-varying covariates. We calculated the relative incidence of seizure compared by vaccine exposure status during the postexposure interval.

Results

Our cohort contained VSD data on 250 601 infants, including 186 502 children fully vaccinated (74.4%) and 64 099 (25.6%) not vaccinated with rotavirus vaccine. Rates of seizures were associated with rotavirus vaccination status. After adjusting for covariates (VSD site, age at last dose, sex, and calendar month of the index date), a statistically significant protective association was observed between a full course of rotavirus vaccination vs no vaccination for both first-ever seizures (risk ratio [RR] = 0.82; 95% confidence interval [CI], .73–.91) and all seizures (RR = 0.79; 95% CI, .71–.88).

Conclusions

A full course of rotavirus vaccination was statistically associated with an 18%–21% reduction in risk of seizure requiring hospitalization or emergency department care in the year following vaccination, compared with unvaccinated children. This reduction in childhood seizures complements the well-documented vaccine-related benefit of preventing US diarrhea hospitalizations.


Subjects:
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Article Child Child, Preschool Cohort Studies Emergency Medical Services Female Hospitalization Humans Infant Male Retrospective Studies Rotavirus Vaccines Seizures Vaccination
Source:
Clin Infect Dis. 58(2):173-177
Pubmed ID:
24265355
Pubmed Central ID:
PMC4618560
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:430e9d4273430e42260e548a914411fa8172c939260d8e0b3b1fe61358b4d18d
Download URL:
https://stacks.cdc.gov/view/cdc/35330/cdc_35330_DS1.pdf
File Type:

Supporting Files

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