Determining the effectiveness of the pentavalent rotavirus vaccine against rotavirus hospitalizations and emergency department visits using two study designs

Donauer, Stephanie; Payne, Daniel C.; Edwards, Kathryn M.; Szilagyi, Peter G.; Hornung, Richard W.; Weinberg, Geoffrey A.; Chappell, James; Hall, Caroline B.; Parashar, Umesh D.; Staat, Mary Allen

doi:10.1016/j.vaccine.2013.03.072

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Determining the effectiveness of the pentavalent rotavirus vaccine against rotavirus hospitalizations and emergency department visits using two study designs

Apr 12 2013
By Donauer, Stephanie ; Payne, Daniel C. ; Edwards, Kathryn M. ; ...
http://dx.doi.org/10.1016/j.vaccine.2013.03.072
Source: Vaccine. 31(24):2692-2697.

[PDF-198.10 KB]

English

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Details:

Alternative Title:

Vaccine
Personal Author:

Donauer, Stephanie ; Payne, Daniel C. ; Edwards, Kathryn M. ; Szilagyi, Peter G. ; Hornung, Richard W. ; ... More +

Donauer, Stephanie ; Payne, Daniel C. ; Edwards, Kathryn M. ; Szilagyi, Peter G. ; Hornung, Richard W. ; Weinberg, Geoffrey A. ; Chappell, James ; Hall, Caroline B. ; Parashar, Umesh D. ; Staat, Mary Allen Less -
Description:

The objective of this study is to determine the vaccine effectiveness (VE) of the pentavalent rotavirus vaccine (RV5) for preventing rotavirus-related hospitalizations and emergency department (ED) visits during the 2006-07 and 2007-08 rotavirus seasons using two study designs. Active, prospective population-based surveillance was conducted to identify cases of laboratory-confirmed rotavirus-related hospitalizations and ED visits to be used in case-cohort and case-control designs. VE was calculated using one comparison group for the case-cohort method and two comparison groups for the case-control method. The VE estimates produced by the three analyses were similar. Three doses of RV5 were effective for preventing rotavirus-related hospitalizations and ED visits in each analysis, with VE estimated as 92% in all three analyses. Two doses of RV5 were also effective, with VE ranging from 79% to 83%. A single dose was effective in the case-cohort analysis, but was not significant in either of the case-control analyses. The case-cohort and the case-control study designs produced the same VE point estimates for completion of the three dose series. Two and three doses of RV5 were effective in preventing rotavirus-related hospitalizations and ED visits.
Subjects:

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Article Case-cohort Studies Case-control Studies Child Child, Preschool Cohort Studies Emergency Service, Hospital Female Gastroenteritis Hospitalization Humans Immunization Infant Male Proportional Hazards Models Prospective Studies Rotavirus Rotavirus Infections Rotavirus Vaccines Vaccination Vaccines, Attenuated
Source:

Vaccine. 31(24):2692-2697.
Pubmed ID:

23583814
Pubmed Central ID:

PMC4618546
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Place as Subject:

New York ; Ohio ; Tennessee

New York ; Ohio ; Tennessee Less -
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:8a4dcbcafa5e512947aa1040bb60c0f8fe168dbb5bbd222c39521e4c66786c69
Download URL:

https://stacks.cdc.gov/view/cdc/35323/cdc_35323_DS1.pdf
File Type:

nihms724444.nxml

bin

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