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Rates and risk factors for hepatitis B reactivation in a cohort of persons in the inactive phase of chronic hepatitis B—Alaska, 2001–2010
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Aug 16 2013
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Source: J Clin Virol 58(2):396-400
[PDF-295.52 KB]
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Alternative Title:J Clin Virol
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Description:Background
A high prevalence of reactivation of hepatitis B has been documented among immunosuppressed individuals in the inactive phase of chronic hepatitis B; However, the proportion of and the risk factors for reactivation are largely unknown among non-immunosuppressed persons
Objectives
Estimate the incidence rate of and risk factors for hepatitis B reactivation in a population-based cohort of persons in the inactive phase of chronic hepatitis B in Alaska
Study design
A cohort of 414 Alaska Native Persons in the inactive phase of hepatitis B (HBV DNA < 2000 IU/mL and normal alanine aminotransferase (ALT) for 12 months) was followed-up for 10 years Reactivation of hepatitis B was defined as HBV DNA ≥ 2000 IU/mL and ALT ≥ 40 IU/L Cox-proportional hazards regression models were used to identify factors associated with reactivation
Results
A total of 36 (9%) persons had reactivation during 2984 person-years of follow-up, with an annual incidence of 12% Persons aged ≥50 years (18%) at study entry had the highest incidence rates of reactivation although incidence rates were not significantly different by age group Risk factors for hepatitis B reactivation were male sex (Hazard Ratio (HR) = 241; 95% Confidence Interval (CI): 117–496), HBV DNA ≥ 1000 IU/mL at study entry (HR = 761; 95% CI: 281–206), and HBV genotype B (HR = 608; 95% CI: 132–280)
Conclusions
The incidence of hepatitis B reactivation was low during the 10 years of follow-up However, given the higher risk of reactivation than their counterparts, males, and those with HBV DNA ≥ 1000 IU/mL need to be followed-up more frequently
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Pubmed ID:24001884
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Pubmed Central ID:PMC4610902
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Volume:58
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Issue:2
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