Mortality Among Patients With Chronic Hepatitis B Infection: The Chronic Hepatitis Cohort Study (CHeCS)

Details

• Alternative Title:
  Clin Infect Dis
• Personal Author:
  Bixler, Danae ; Zhong, Yuna ; Ly, Kathleen N. ; Moorman, Anne C. ; Spradling, Philip R. ; Teshale, Eyasu H. ; Rupp, Loralee B. ; Gordon, Stuart C. ; Boscarino, Joseph A. ; Schmidt, Mark A. ; Daida, Yihe G. ; Holmberg, Scott D.
  More +
• Corporate Authors:
  CHeCS Investigators
• Description:
  Background. ; According to death certificates, approximately 1800 persons die from hepatitis B annually in the United States; however, this figure may underestimate true mortality from chronic hepatitis B (CHB). ; Methods. ; We analyzed data from CHB patients seen in the Chronic Hepatitis Cohort Study (CHeCS) between 1 January 2006 and 31 December 2013. We compared overall and cause-specific death rates and mean ages at death between CHeCS CHB decedents and U.S. decedents from the Multiple Cause of Death (MCOD) file. ; Results. ; Of 4389 CHB patients followed for a mean of 5.38 years, 492 (11%) CHB patients died after a mean follow-up of 3.00 years. Compared to survivors, decedents were older, more likely to be White (40.6%), African-American (27.1%), or male (74.2%); and more likely to have had cirrhosis (59.8%), diabetes (27.2%), alcohol abuse (17.7%), hepatocellular carcinoma (17.5%), or a liver transplant (5.7%); whereas survivors were more likely to be Asian (48.8%; all P < .001). CHB patients died at an average age of 59.8 years—14 years younger than the general U.S. population—and at higher rates for all causes (relative risk RR = 1.85, 95% confidence interval CI, 1.851–1.857) and liver-related causes (RR = 15.91, 95% CI, 15.81–16.01). Only 19% of CHB decedents and 40% of those dying of liver disease had hepatitis B reported on their death certificates. ; Conclusions. ; Compared to the general population, CHB patients die at younger ages and higher rates from all causes and liver-related causes. Death certificates underrepresent the true mortality from CHB.
• Subjects:
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cause of Death
  • Female
  • Follow-Up Studies
  • Hepatitis B virus
  • Hepatitis B, Chronic
  • Humans
  More +
• Keywords:
  • chronic hepatitis B
  • mortality
  • liver disease
  • risk factors
  • cause of death
• Source:
  Clin Infect Dis. 68(6):956-963
• Pubmed ID:
  30060032
• Pubmed Central ID:
  PMC11230463
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U18 PS005154/PS/NCHHSTP CDC HHSUnited States/
• Volume:
  68
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/158527/cdc_158527_DS1.pdf
• File Type:
  [PDF - 132.48 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c169842212657a6f2cc1a823bf706b0f1ce940d92b72982329e4ce0cc731e263