Details:

Alternative Title:
Pediatrics
Personal Author:
Broussard, Cheryl S. ; Gilboa, Suzanne M. ; Lee, Kyung A. ; Oster, Matthew ; Petrini, Joann R. ; ... More +
Broussard, Cheryl S. ; Gilboa, Suzanne M. ; Lee, Kyung A. ; Oster, Matthew ; Petrini, Joann R. ; Honein, Margaret A. Less -
Description:
Objective

Birth defects are a leading cause of infant mortality in the United States. Previous reports have highlighted black-white differences in overall infant mortality and infant mortality attributable to birth defects (IMBD). We evaluated the impact of gestational age on US racial/ethnic differences in IMBD.

Methods

We estimated the rate of IMBD (using ICD-10 codes for the underlying cause of death) using the period linked birth/infant death data for US residents for January 2003 to December 2006. We excluded infants with missing gestational age, implausible values based on Alexander’s index of birth weight for gestational age norms, or gestational ages <20 weeks or >44 weeks; we categorized gestational age into three groups: 20–33; 34–36; and 37–44 weeks. Using Poisson regression, we compared neonatal and postneonatal mortality attributable to birth defects for infants of non-Hispanic black and Hispanic mothers with that for infants of non-Hispanic white mothers stratified by gestational age.

Results

IMBD occurred in 12.2 per 10,000 live births. Among infants delivered at 37–44 weeks, blacks (and Hispanics, to a lesser degree) had significantly higher neonatal and postneonatal mortality attributable to birth defects than whites. However, among infants delivered at 20–33 or 34–36 weeks, neonatal (but not postneonatal) mortality attributable to birth defects was significantly lower among blacks compared with whites.

Conclusions

Racial/ethnic differences in IMBD were not explained in these data by differences in gestational age. Further investigation should include an assessment of possible racial/ethnic differences in severity and/or access to timely diagnosis and management of birth defects.


Subjects:
[+]
Black Or African American Congenital Abnormalities Gestational Age Hispanic Or Latino Humans Infant Infant, Newborn White
Source:
Pediatrics. 130(3):e518-e527.
Pubmed ID:
22908111
Pubmed Central ID:
PMC4605418
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b3c47a99daedc47b6c98991c8d6bee068d929e692067a2d1c920d3508d66dc7b
Download URL:
https://stacks.cdc.gov/view/cdc/34964/cdc_34964_DS1.pdf
File Type:

Supporting Files

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