Details:

Alternative Title:
Clin Infect Dis
Personal Author:
Meltzer, Martin I. ; Patel, Anita ; Koonin, Lisa M.
Meltzer, Martin I. ; Patel, Anita ; Koonin, Lisa M. Less -
Description:
An outbreak in China in April 2013 of human illnesses due to avian influenza A(H7N9) virus provided reason for US public health officials to revisit existing national pandemic response plans. We built a spreadsheet model to examine the potential demand for invasive mechanical ventilation (excluding "rescue therapy" ventilation). We considered scenarios of either 20% or 30% gross influenza clinical attack rate (CAR), with a "low severity" scenario with case fatality rates (CFR) of 0.05%-0.1%, or a "high severity" scenario (CFR: 0.25%-0.5%). We used rates-of-influenza-related illness to calculate the numbers of potential clinical cases, hospitalizations, admissions to intensive care units, and need for mechanical ventilation. We assumed 10 days ventilator use per ventilated patient, 13% of total ventilator demand will occur at peak, and a 33.7% weighted average mortality risk while on a ventilator. At peak, for a 20% CAR, low severity scenario, an additional 7000 to 11,000 ventilators will be needed, averting a pandemic total of 35,000 to 55,000 deaths. A 30% CAR, high severity scenario, will need approximately 35,000 to 60,500 additional ventilators, averting a pandemic total 178,000 to 308,000 deaths. Estimates of deaths averted may not be realized because successful ventilation also depends on sufficient numbers of suitably trained staff, needed supplies (eg, drugs, reliable oxygen sources, suction apparatus, circuits, and monitoring equipment) and timely ability to match access to ventilators with critically ill cases. There is a clear challenge to plan and prepare to meet demands for mechanical ventilators for a future severe pandemic.
Subjects:
[+]
Article Demand Disaster Planning Humans Influenza, Human Influenza A Virus, H7N9 Subtype Influenza Pandemic Intensive Care Units Models, Theoretical Pandemics Public Health Respiration, Artificial United States Ventilation Ventilator Ventilators, Mechanical
Source:
Clin Infect Dis. 60(0 1):S52-S57
Pubmed ID:
25878301
Pubmed Central ID:
PMC4603361
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/ ; T32 GM007752/GM/NIGMS NIH HHSUnited States/
CC999999/Intramural CDC HHSUnited States/ ; T32 GM007752/GM/NIGMS NIH HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:57be0731be84d36eb97fd109ddf19518f22056fe012a28525a57f55b64a52005
Download URL:
https://stacks.cdc.gov/view/cdc/34930/cdc_34930_DS1.pdf
File Type:

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