Details:

Alternative Title:
Nanotoxicology
Publisher's site:
http://dx.doi.org/10.3109/17435390.2013.801089
Personal Author:
Wang, Liying ; Stueckle, Todd A. ; Mishra, Anurag ; Derk, Raymond ; Meighan, Terence ; ... More +
Wang, Liying ; Stueckle, Todd A. ; Mishra, Anurag ; Derk, Raymond ; Meighan, Terence ; Castranova, Vincent ; Rojanasakul, Yon Less -
Description:
Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology and mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk of CNT-induced lung carcinogenesis; however, relatively little is known about the long-term carcinogenic effect of CNT. Neoplastic transformation is a key early event leading to carcinogenesis. We studied the ability of single- and multi-walled CNTs to induce neoplastic transformation of human lung epithelial cells compared to asbestos. Long-term (6-month) exposure of the cells to occupationally relevant concentrations of CNT in culture caused a neoplastic-like transformation phenotype as demonstrated by increased cell proliferation, anchorage-independent growth, invasion and angiogenesis. Whole-genome expression signature and protein expression analyses showed that single- and multi-walled CNTs shared similar signaling signatures which were distinct from asbestos. These results provide novel toxicogenomic information and suggest distinct particle-associated mechanisms of neoplasia promotion induced by CNTs and asbestos.
Subject:
[+]
Article
Asbestos
Cell Line
Cell Transformation, Neoplastic
Epithelial Cells
Gene Expression Profiling
Genome Expression
Humans
Invasion
Lung
Microarray
Nanotubes, Carbon
Neoplastic Transformation
Proteins
Respiratory Mucosa
Signal Transduction

Source:
Nanotoxicology. 8(5):485-507.
Pubmed ID:
23634900
Pubmed Central ID:
PMC4599578
Document Type:
Journal Article
Funding:
1001560224/Intramural CDC HHS/United States ; R01-HL095579/HL/NHLBI NIH HHS/United States
1001560224/Intramural CDC HHS/United States ; R01-HL095579/HL/NHLBI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:11cf82a97d39f8b87eebacc2790dfb6fe446a1f105bc01f7fb6c9ec573dd4605
File Type:

Supporting Files

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