Serum Non-high-density lipoprotein cholesterol concentration and risk of death from cardiovascular diseases among U.S. adults with diagnosed diabetes: the Third National Health and Nutrition Examination Survey linked mortality study

Details

• Alternative Title:
  Cardiovasc Diabetol
• Personal Author:
  Li, Chaoyang ; Ford, Earl S ; Tsai, James ; Zhao, Guixiang ; Balluz, Lina S ; Gidding, Samuel S
• Description:
  Background
  
  Non-high-density lipoprotein cholesterol (non-HDL-C) measures all atherogenic apolipoprotein B-containing lipoproteins and predicts risk of cardiovascular diseases (CVD). The association of non-HDL-C with risk of death from CVD in diabetes is not well understood. This study assessed the hypothesis that, among adults with diabetes, non-HDL-C may be related to the risk of death from CVD.
  
  Methods
  
  We analyzed data from 1,122 adults aged 20 years and older with diagnosed diabetes who participated in the Third National Health and Nutrition Examination Survey linked mortality study (299 deaths from CVD according to underlying cause of death; median follow-up length, 12.4 years).
  
  Results
  
  Compared to participants with serum non-HDL-C concentrations of 35 to 129 mg/dL, those with higher serum levels had a higher risk of death from total CVD: the RRs were 1.34 (95% CI: 0.75-2.39) and 2.25 (95% CI: 1.30-3.91) for non-HDL-C concentrations of 130-189 mg/dL and 190-403 mg/dL, respectively (P = 0.003 for linear trend) after adjustment for demographic characteristics and selected risk factors. In subgroup analyses, significant linear trends were identified for the risk of death from ischemic heart disease: the RRs were 1.59 (95% CI: 0.76-3.32) and 2.50 (95% CI: 1.28-4.89) (P = 0.006 for linear trend), and stroke: the RRs were 3.37 (95% CI: 0.95-11.90) and 5.81 (95% CI: 1.96-17.25) (P = 0.001 for linear trend).
  
  Conclusions
  
  In diabetics, higher serum non-HDL-C concentrations were significantly associated with increased risk of death from CVD. Our prospective data support the notion that reducing serum non-HDL-C concentrations may be beneficial in the prevention of excess death from CVD among affected adults.
  
  
• Subjects:
  Adult Biological Markers Cardiovascular Diseases Cause Of Death Chi-Square Distribution Cholesterol Diabetes Complications Diabetes Mellitus Dyslipidemias Humans Linear Models Middle Aged Nutrition Surveys Proportional Hazards Models Prospective Studies Risk Assessment Risk Factors Time Factors Up-Regulation Young Adult

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• Source:
  Cardiovasc Diabetol. 2011; 10:46.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5060cfda60a0f8d92bdc0cbf76b1fb1d6f77278c5a56d0211a3bdb40c51f152b
• Download URL:
  https://stacks.cdc.gov/view/cdc/3485/cdc_3485_DS1.pdf
• File Type:
  [PDF - 392.00 KB ]