Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis

Details

• Alternative Title:
  Int J Tuberc Lung Dis
• Personal Author:
  Smith, Sarah E ; Kurbatova, Ekaterina V ; Cavanaugh, Joseph S ; Cegielski, J Peter
• Description:
  Following the World Health Organization's endorsement of the Xpert® MTB/RIF assay, which rapidly and simultaneously diagnoses tuberculosis (TB) and detects resistance to rifampin (RMP), the question arises to what extent RMP resistance is an adequate marker for multidrug-resistant TB (MDR-TB). A retrospective analysis of data from >81 countries and subnational settings demonstrated that >40% of RMP-resistant isolates from new TB cases did not display resistance to isoniazid (INH) in settings with relatively low MDR-TB prevalence (one third of all countries and subnational settings). Results indicated the need for INH susceptibility testing in addition to RMP susceptibility testing.
• Subjects:
  Antitubercular Agents Article Global Health Humans Incidence Isoniazid Mycobacterium Tuberculosis Prevalence Retrospective Studies Rifampin Tuberculosis, Multidrug-Resistant

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• Source:
  Int J Tuberc Lung Dis. 16(2):203-205
• Pubmed ID:
  22136739
• Pubmed Central ID:
  PMC4593497
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  16
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c7fcff1b52238e5a61c90a4280c5a46fc0959084b1b713fc6bb1a6f48f7ac0ca
• Download URL:
  https://stacks.cdc.gov/view/cdc/34756/cdc_34756_DS1.pdf
• File Type:
  [PDF - 96.51 KB ]