Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis

Smith, Sarah E; Kurbatova, Ekaterina V; Cavanaugh, Joseph S; Cegielski, J Peter

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Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis

Published Date:

2012 Feb

Source:

Int J Tuberc Lung Dis. 16(2):203-205

Language:

English

[PDF-96.51 KB]

Details:

Alternative Title:

Int J Tuberc Lung Dis

Personal Author:

Smith, Sarah E ; Kurbatova, Ekaterina V ; Cavanaugh, Joseph S ; Cegielski, J Peter ;

Description:

Following the World Health Organization's endorsement of the Xpert® MTB/RIF assay, which rapidly and simultaneously diagnoses tuberculosis (TB) and detects resistance to rifampin (RMP), the question arises to what extent RMP resistance is an adequate marker for multidrug-resistant TB (MDR-TB). A retrospective analysis of data from >81 countries and subnational settings demonstrated that >40% of RMP-resistant isolates from new TB cases did not display resistance to isoniazid (INH) in settings with relatively low MDR-TB prevalence (one third of all countries and subnational settings). Results indicated the need for INH susceptibility testing in addition to RMP susceptibility testing.

Subject:

[+]

Pubmed ID:

22136739

Pubmed Central ID:

PMC4593497

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

nihms725526.nxml

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Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis

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