Details:

Alternative Title:
Int J Tuberc Lung Dis
Personal Author:
Smith, Sarah E ; Kurbatova, Ekaterina V ; Cavanaugh, Joseph S ; Cegielski, J Peter
Smith, Sarah E ; Kurbatova, Ekaterina V ; Cavanaugh, Joseph S ; Cegielski, J Peter Less -
Description:
Following the World Health Organization's endorsement of the Xpert® MTB/RIF assay, which rapidly and simultaneously diagnoses tuberculosis (TB) and detects resistance to rifampin (RMP), the question arises to what extent RMP resistance is an adequate marker for multidrug-resistant TB (MDR-TB). A retrospective analysis of data from >81 countries and subnational settings demonstrated that >40% of RMP-resistant isolates from new TB cases did not display resistance to isoniazid (INH) in settings with relatively low MDR-TB prevalence (one third of all countries and subnational settings). Results indicated the need for INH susceptibility testing in addition to RMP susceptibility testing.
Subject:
[+]
Antitubercular Agents
Article
Global Health
Humans
Incidence
Isoniazid
Mycobacterium Tuberculosis
Prevalence
Retrospective Studies
Rifampin
Tuberculosis, Multidrug-Resistant

Source:
Int J Tuberc Lung Dis. 16(2):203-205
Pubmed ID:
22136739
Pubmed Central ID:
PMC4593497
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c7fcff1b52238e5a61c90a4280c5a46fc0959084b1b713fc6bb1a6f48f7ac0ca
File Type:

Supporting Files

• nihms725526.nxml

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