Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis

Smith, Sarah E.; Kurbatova, Ekaterina V.; Cavanaugh, Joseph S.; Cegielski, J. Peter

doi:10.5588/ijtld.11.0445

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Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis

Published Date:

Feb 2012

Publisher's site:

http://dx.doi.org/10.5588/ijtld.11.0445 New Site Icon

Source:

Int J Tuberc Lung Dis. 16(2):203-205.

Language:

English

[PDF-96.51 KB]

Details:

Personal Authors:

Smith, Sarah E. ; Kurbatova, Ekaterina V. ; Cavanaugh, Joseph S. ; Cegielski, J. Peter ;

Keywords:

[+]

Pubmed ID:

22136739

Pubmed Central ID:

PMC4593497

Description:

Following the World Health Organization's endorsement of the Xpert® MTB/RIF assay, which rapidly and simultaneously diagnoses tuberculosis (TB) and detects resistance to rifampin (RMP), the question arises to what extent RMP resistance is an adequate marker for multidrug-resistant TB (MDR-TB). A retrospective analysis of data from >81 countries and subnational settings demonstrated that >40% of RMP-resistant isolates from new TB cases did not display resistance to isoniazid (INH) in settings with relatively low MDR-TB prevalence (one third of all countries and subnational settings). Results indicated the need for INH susceptibility testing in addition to RMP susceptibility testing.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1000553038/Intramural CDC HHS/United States
IES3/Intramural CDC HHS/United States

Supporting Files:

nihms725526.nxml

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