Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010

Auguste, Albert J.; Liria, Jonathan; Forrester, Naomi L.; Giambalvo, Dileyvic; Moncada, Maria; Long, Kanya C.; Morón, Dulce; de Manzione, Nuris; Tesh, Robert B.; Halsey, Eric S.; Kochel, Tadeusz J.; Hernandez, Rosa; Navarro, Juan-Carlos; Weaver, Scott C.

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Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010

Supporting Files Public Domain

Oct 2015
By Auguste, Albert J. ; Liria, Jonathan ; Forrester, Naomi L. ; ...

File Language:

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Auguste, Albert J. ; Liria, Jonathan ; Forrester, Naomi L. ; Giambalvo, Dileyvic ; Moncada, Maria ; Long, Kanya C. ; Morón, Dulce ; de Manzione, Nuris ; Tesh, Robert B. ; Halsey, Eric S. ; Kochel, Tadeusz J. ; Hernandez, Rosa ; Navarro, Juan-Carlos ; Weaver, Scott C.
Description:

In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acute-phase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.
Subjects:

Alphavirus Alphavirus Infections Biological Evolution Biota Coalescent Analysis Disease Outbreaks Ecology Epidemic Evolution Evolutionary And Ecological Characterization Of Mayaro Virus Strains Isolated During An Outbreak, Venezuela, 2010 Female Humans Male Mayaro Virus Niche Modeling Outbreak Phylogeny Research Venezuela Viruses Zoonoses
Source:

Emerg Infect Dis. 21(10):1742-1750
Document Type:

Journal Article
Volume:

21
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha-512:f3282d25cafba71bc325770dee237898769bc440e44e39f6feb83c0683600814fc3c2fa925ca4ff5265000dae8b5db0164ef8f65d249e515bcd5b40fea66e963
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https://stacks.cdc.gov/view/cdc/34702/cdc_34702_DS1.pdf
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[PDF - 622.37 KB ]

File Language:

English

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