The Look AHEAD Trial: Bone Loss at 4-Year Follow-up in Type 2 Diabetes

Details

• Alternative Title:
  Diabetes Care
• Personal Author:
  Lipkin, Edward W. ; Schwartz, Ann V. ; Anderson, Andrea M. ; Davis, Cralen ; Johnson, Karen C. ; Gregg, Edward W. ; Bray, George A. ; Berkowitz, Robert ; Peters, Anne L. ; Hodges, Amelia ; Lewis, Cora ; Kahn, Steven E.
• Corporate Authors:
  Look AHEAD Research Group
• Description:
  OBJECTIVE
  
  To determine whether an intensive lifestyle intervention (ILI) designed to sustain weight loss and improve physical fitness in overweight or obese persons with type 2 diabetes was associated with bone loss after 4 years of follow-up.
  
  RESEARCH DESIGN AND METHODS
  
  This randomized controlled trial of intensive weight loss compared an ILI with a diabetes support and education (DSE) group among 1,309 overweight or obese subjects. Bone mineral density was assessed at baseline and after 1 year and 4 years of intervention.
  
  RESULTS
  
  ILI was effective in producing significant weight loss (5.3% vs. 1.8% in ILI and DSE, respectively; P < 0.01) and increased fitness (6.4% vs. −0.8%) at year 4. In men, ILI participants had a greater rate of bone loss during the first year (−1.66% vs. −0.09% per year in ILI and DSE, respectively). Differences between groups were diminished by one-half after 4 years (−0.88% vs. −0.05% per year in ILI and DSE, respectively) but remained significant (P < 0.01). The difference in rate of hip bone loss between groups over 4 years was related to increased weight loss in ILI. Among women, the rate of bone loss did not differ between ILI and DSE after 4 years.
  
  CONCLUSIONS
  
  A 4-year weight loss intervention was significantly associated with a modest increase in bone loss at the hip in men but not in women.
  
  
• Subjects:
  Aged Bone Density Cardiovascular And Metabolic Risk Diabetes Mellitus, Type 2 Female Follow-Up Studies Humans Life Style Male Middle Aged Obesity Osteoporosis Overweight Physical Fitness Weight Loss Weight Reduction Programs

  More +
• Source:
  Diabetes Care. 2014; 37(10):2822-2829.
• Pubmed ID:
  25048381
• Pubmed Central ID:
  PMC4170123
• Document Type:
  Journal Article
• Funding:
  DK-046204/DK/NIDDK NIH HHS/United States ; DK-56990/DK/NIDDK NIH HHS/United States ; DK-56992/DK/NIDDK NIH HHS/United States ; DK-57002/DK/NIDDK NIH HHS/United States ; DK-57008/DK/NIDDK NIH HHS/United States ; DK-57078/DK/NIDDK NIH HHS/United States ; DK-57131/DK/NIDDK NIH HHS/United States ; DK-57135/DK/NIDDK NIH HHS/United States ; DK-57136/DK/NIDDK NIH HHS/United States ; DK-57149/DK/NIDDK NIH HHS/United States ; DK-57151/DK/NIDDK NIH HHS/United States ; DK-57154/DK/NIDDK NIH HHS/United States ; DK-57171/DK/NIDDK NIH HHS/United States ; DK-57177/DK/NIDDK NIH HHS/United States ; DK-57178/DK/NIDDK NIH HHS/United States ; DK-57182/DK/NIDDK NIH HHS/United States ; DK-57219/DK/NIDDK NIH HHS/United States ; M01-RR-000056/RR/NCRR NIH HHS/United States ; M01-RR-00051/RR/NCRR NIH HHS/United States ; M01-RR-0021140/RR/NCRR NIH HHS/United States ; M01-RR-01066/RR/NCRR NIH HHS/United States ; M01-RR-01346/RR/NCRR NIH HHS/United States ; M01-RR-02719/RR/NCRR NIH HHS/United States ; P30 DK017047/DK/NIDDK NIH HHS/United States ; P30 DK079626/DK/NIDDK NIH HHS/United States ; P30-DK-48520/DK/NIDDK NIH HHS/United States ; UL1-RR-024153/RR/NCRR NIH HHS/United States
• Volume:
  37
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:735c087ea4275bc45d021e296cb505d4c31c7f7a0e2f88a7edc9e4d5a9cb1eb9
• Download URL:
  https://stacks.cdc.gov/view/cdc/34690/cdc_34690_DS1.pdf
• File Type:
  [PDF - 788.19 KB ]