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The Look AHEAD Trial: Bone Loss at 4-Year Follow-up in Type 2 Diabetes
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Details:
  • Corporate Authors:
    Look AHEAD Research Group
  • Pubmed ID:
    25048381
  • Pubmed Central ID:
    PMC4170123
  • Description:
    OBJECTIVE

    To determine whether an intensive lifestyle intervention (ILI) designed to sustain weight loss and improve physical fitness in overweight or obese persons with type 2 diabetes was associated with bone loss after 4 years of follow-up.

    RESEARCH DESIGN AND METHODS

    This randomized controlled trial of intensive weight loss compared an ILI with a diabetes support and education (DSE) group among 1,309 overweight or obese subjects. Bone mineral density was assessed at baseline and after 1 year and 4 years of intervention.

    RESULTS

    ILI was effective in producing significant weight loss (5.3% vs. 1.8% in ILI and DSE, respectively; P < 0.01) and increased fitness (6.4% vs. −0.8%) at year 4. In men, ILI participants had a greater rate of bone loss during the first year (−1.66% vs. −0.09% per year in ILI and DSE, respectively). Differences between groups were diminished by one-half after 4 years (−0.88% vs. −0.05% per year in ILI and DSE, respectively) but remained significant (P < 0.01). The difference in rate of hip bone loss between groups over 4 years was related to increased weight loss in ILI. Among women, the rate of bone loss did not differ between ILI and DSE after 4 years.

    CONCLUSIONS

    A 4-year weight loss intervention was significantly associated with a modest increase in bone loss at the hip in men but not in women.

  • Document Type:
  • Collection(s):
  • Funding:
    DK-046204/DK/NIDDK NIH HHS/United States
    DK-56990/DK/NIDDK NIH HHS/United States
    DK-56992/DK/NIDDK NIH HHS/United States
    DK-57002/DK/NIDDK NIH HHS/United States
    DK-57008/DK/NIDDK NIH HHS/United States
    DK-57078/DK/NIDDK NIH HHS/United States
    DK-57131/DK/NIDDK NIH HHS/United States
    DK-57135/DK/NIDDK NIH HHS/United States
    DK-57136/DK/NIDDK NIH HHS/United States
    DK-57149/DK/NIDDK NIH HHS/United States
    DK-57151/DK/NIDDK NIH HHS/United States
    DK-57154/DK/NIDDK NIH HHS/United States
    DK-57171/DK/NIDDK NIH HHS/United States
    DK-57177/DK/NIDDK NIH HHS/United States
    DK-57178/DK/NIDDK NIH HHS/United States
    DK-57182/DK/NIDDK NIH HHS/United States
    DK-57219/DK/NIDDK NIH HHS/United States
    M01-RR-000056/RR/NCRR NIH HHS/United States
    M01-RR-00051/RR/NCRR NIH HHS/United States
    M01-RR-0021140/RR/NCRR NIH HHS/United States
    M01-RR-01066/RR/NCRR NIH HHS/United States
    M01-RR-01346/RR/NCRR NIH HHS/United States
    M01-RR-02719/RR/NCRR NIH HHS/United States
    P30 DK017047/DK/NIDDK NIH HHS/United States
    P30 DK079626/DK/NIDDK NIH HHS/United States
    P30-DK-48520/DK/NIDDK NIH HHS/United States
    UL1-RR-024153/RR/NCRR NIH HHS/United States
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