The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system

Details

• Alternative Title:
  Arch Virol
• Personal Author:
  Clark, David C. ; Brault, Aaron C. ; Hunsperger, Elizabeth
• Description:
  Members of the genus Flavivirus are responsible for a spectrum of important neurological syndromes in humans and animals. Rodent models have been used extensively to model flavivirus neurological disease, to discover host-pathogen interactions that influence disease outcome, and as surrogates to determine the efficacy and safety of vaccines and therapeutics. In this review, we discuss the current understanding of flavivirus neuroinvasive disease and outline the host, viral and experimental factors that influence the outcome and reliability of virus infection of small-animal models.
• Subjects:
  Animals Central Nervous System Cricetinae Disease Models, Animal Encephalitis, Viral Flavivirus Flavivirus Infections Host-Pathogen Interactions Insect Vectors Mice Rodentia

  More +
• Source:
  Arch Virol. 157(8):1423-1440.
• Document Type:
  Journal Article
• Volume:
  157
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:99548e01eedb9cf75f42c207a982990b7ab4e7184ef8daf549952e2d12d068f26e33387433ed010f15d49f075e78fc620375d3a674ac865adae98288b35c3212
• Download URL:
  https://stacks.cdc.gov/view/cdc/34591/cdc_34591_DS1.pdf
• File Type:
  [PDF - 225.16 KB ]