Work-Related Spirometric Restriction in Flavoring Manufacturing Workers

Details

• Journal Article:
  Am J Ind Med
• Personal Author:
  Kreiss, Kathleen
• Description:
  Background
  
  Flavoring-exposed workers are at risk for occupational lung disease.
  
  Methods
  
  We examined serial spirometries from corporate medical surveillance of flavoring production workers to assess abnormality compared to the U.S. population; mean decline in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC); and excessive declines in FEV1.
  
  Results
  
  Of 106 workers, 30 had spirometric restriction, 3 had obstruction, 1 had both, and 13 (of 70, 19%) had excessive declines in FEV1. The adjusted prevalence of restriction was 3.7 times expected. Employees with higher potential for flavorings exposure had 3.0 times and 2.4 times greater average annual declines in FEV1 and FVC respectively, and had 5.8 times higher odds of having excessive FEV1 declines than employees with lower potential for exposure.
  
  Conclusion
  
  Exposure-related spirometric abnormalities consistent with a restrictive process evolved during employment, suggesting that exposures in flavoring production are associated with a range of pathophysiology.
  
  
• Subjects:
  Adult Aged Article Chemical Industry Diacetyl Excessive Decline Female Flavoring Agents Flavorings Forced Expiratory Volume Humans Hydrogen Sulfide Inhalation Exposure Longitudinal Studies Lung Diseases, Obstructive Male Middle Aged Occupational Diseases Occupational Exposure Respiratory System Spirometric Restriction Spirometry Time Factors Vital Capacity Young Adult

  More +
• Source:
  Am J Ind Med. 57(2):129-137
• Pubmed ID:
  24265107
• Pubmed Central ID:
  PMC4586123
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  57
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:8ec18525df1b135fbba6f297d30a13b93ce102cbed000a4c2f8bb16a13d74eaa917c0bd91c20c8802ecbde3862e94f7e7862edad55323e83fe8dfda6f7b506e9
• Download URL:
  https://stacks.cdc.gov/view/cdc/34539/cdc_34539_DS1.pdf
• File Type:
  [PDF - 293.75 KB ]