Work-Related Spirometric Restriction in Flavoring Manufacturing Workers

Kreiss, Kathleen

doi:10.1002/ajim.22282

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Work-Related Spirometric Restriction in Flavoring Manufacturing Workers

Published Date:

Nov 22 2013

Publisher's site:

http://dx.doi.org/10.1002/ajim.22282 New Site Icon

Source:

Am J Ind Med. 57(2):129-137.

[PDF-293.75 KB]

Details:

Personal Authors:

Kreiss, Kathleen

Keywords:

[+]

Pubmed ID:

24265107

Pubmed Central ID:

PMC4586123

Description:

Background

Flavoring-exposed workers are at risk for occupational lung disease.

Methods

We examined serial spirometries from corporate medical surveillance of flavoring production workers to assess abnormality compared to the U.S. population; mean decline in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC); and excessive declines in FEV1.

Results

Of 106 workers, 30 had spirometric restriction, 3 had obstruction, 1 had both, and 13 (of 70, 19%) had excessive declines in FEV1. The adjusted prevalence of restriction was 3.7 times expected. Employees with higher potential for flavorings exposure had 3.0 times and 2.4 times greater average annual declines in FEV1 and FVC respectively, and had 5.8 times higher odds of having excessive FEV1 declines than employees with lower potential for exposure.

Conclusion

Exposure-related spirometric abnormalities consistent with a restrictive process evolved during employment, suggesting that exposures in flavoring production are associated with a range of pathophysiology.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

KLB9/Intramural CDC HHS/United States

Main Document Checksum:

[+]

Supporting Files:

	NIHMS722054-supplement-figures.pdf	application/pdf
	nihms722054.nxml	text/plain
	nihms722054f1.gif	image/gif
	nihms722054f1.jpg	image/jpeg

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