Details:

Alternative Title:
Am J Ind Med
Personal Author:
Kreiss, Kathleen;
Description:
Background Flavoring-exposed workers are at risk for occupational lung disease. Methods We examined serial spirometries from corporate medical surveillance of flavoring production workers to assess abnormality compared to the U.S. population; mean decline in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC); and excessive declines in FEV1. Results Of 106 workers, 30 had spirometric restriction, 3 had obstruction, 1 had both, and 13 (of 70, 19%) had excessive declines in FEV1. The adjusted prevalence of restriction was 3.7 times expected. Employees with higher potential for flavorings exposure had 3.0 times and 2.4 times greater average annual declines in FEV1 and FVC respectively, and had 5.8 times higher odds of having excessive FEV1 declines than employees with lower potential for exposure. Conclusion Exposure-related spirometric abnormalities consistent with a restrictive process evolved during employment, suggesting that exposures in flavoring production are associated with a range of pathophysiology.
Subject:
[+]
Adult
Aged
Article
Chemical Industry
Diacetyl
Excessive Decline
Female
Flavoring Agents
Flavorings
Forced Expiratory Volume
Humans
Hydrogen Sulfide
Inhalation Exposure
Longitudinal Studies
Lung Diseases, Obstructive
Male
Middle Aged
Occupational Diseases
Occupational Exposure
Respiratory System
Spirometric Restriction
Spirometry
Time Factors
Vital Capacity
Young Adult
Spirometry

Source:
Am J Ind Med. 57(2):129-137;
Pubmed ID:
24265107
Pubmed Central ID:
PMC4586123
Document Type:
Journal Article;
Funding:
CC999999/Intramural CDC HHS/United States;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:744035809bfebb0558a10505159f0709912ac9b261c6aa814a85d4045210f1ec
File Type:

Supporting Files

• 	NIHMS722054-supplement-figures.pdf	pdf
  	nihms722054.nxml	xml
  	nihms722054f1.gif	gif
  	nihms722054f1.jpg	jpeg

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