Intergenerational Continuity in Parents’ and Adolescents’ Externalizing Problems: The Role of Life Events and their Interaction with GABRA2

Details

• Alternative Title:
  J Abnorm Psychol
• Personal Author:
  Salvatore, Jessica E. ; Meyers, Jacquelyn L. ; Yan, Jia ; Aliev, Fazil ; Lansford, Jennifer E. ; Pettit, Gregory S. ; Bates, John E. ; Dodge, Kenneth A. ; Rose, Richard J. ; Pulkkinen, Lea ; Kaprio, Jaakko ; Dick, Danielle M.
• Description:
  We examine whether parental externalizing behavior has an indirect effect on adolescent externalizing behavior via elevations in life events, and whether this indirect effect is further qualified by an interaction between life events and adolescents' GABRA2 genotype (rs279871). We use data from 2 samples: the Child Development Project (CDP; n = 324) and FinnTwin12 (n = 802). In CDP, repeated measures of life events, mother-reported adolescent externalizing, and teacher-reported adolescent externalizing were used. In FinnTwin12, life events and externalizing were assessed at age 14. Parental externalizing was indexed by measures of antisocial behavior and alcohol problems or alcohol dependence symptoms in both samples. In CDP, parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p ≤ .05). The association between life events and subsequent adolescent externalizing was stronger for adolescents with 0 copies of the G minor allele compared to those with 1 or 2 copies of the minor allele. Parallel moderation trends were observed in FinnTwin12 (p ≤ .11). The discussion focuses on how the strength of intergenerational pathways for externalizing psychopathology may differ as a function of adolescent-level individual differences.
• Subjects:
  Article Externalizing GABRA2 Gene-environment Interaction Intergenerational Continuity Life Events
• Source:
  J Abnorm Psychol. 124(3):709-728.
• Pubmed ID:
  26075969
• Pubmed Central ID:
  PMC4573794
• Document Type:
  Journal Article
• Funding:
  AA-09203/AA/NIAAA NIH HHS/United States ; AA00145/AA/NIAAA NIH HHS/United States ; AA12502/AA/NIAAA NIH HHS/United States ; AA15416/AA/NIAAA NIH HHS/United States ; DA016903/DA/NIDA NIH HHS/United States ; F32 AA022269/AA/NIAAA NIH HHS/United States ; F32AA022269/AA/NIAAA NIH HHS/United States ; H13 DP424981/DP/NCCDPHP CDC HHS/United States ; HD30572/HD/NICHD NIH HHS/United States ; K01 DA037914/DA/NIDA NIH HHS/United States ; K02 AA018755/AA/NIAAA NIH HHS/United States ; K02AA018755/AA/NIAAA NIH HHS/United States ; K05 AA000145/AA/NIAAA NIH HHS/United States ; L30 AA014504/AA/NIAAA NIH HHS/United States ; MH057024-07S1/MH/NIMH NIH HHS/United States ; MH42498/MH/NIMH NIH HHS/United States ; MH56961/MH/NIMH NIH HHS/United States ; MH57024/MH/NIMH NIH HHS/United States ; MH57095/MH/NIMH NIH HHS/United States ; R01 AA009203/AA/NIAAA NIH HHS/United States ; R01 AA012502/AA/NIAAA NIH HHS/United States ; R01 AA015416/AA/NIAAA NIH HHS/United States ; R01 DA016903/DA/NIDA NIH HHS/United States ; R01 HD030572/HD/NICHD NIH HHS/United States ; R01 MH042498/MH/NIMH NIH HHS/United States ; R01 MH056961/MH/NIMH NIH HHS/United States ; R01 MH057024/MH/NIMH NIH HHS/United States ; R01 MH057095/MH/NIMH NIH HHS/United States ; R37 AA012502/AA/NIAAA NIH HHS/United States ; T32 MH020030/MH/NIMH NIH HHS/United States ; T32MH20030-14/MH/NIMH NIH HHS/United States
• Volume:
  124
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e21c3f43a82833846679513d8a6413eb7baa7d54f5e9a4a085854da852776ca1
• Download URL:
  https://stacks.cdc.gov/view/cdc/34351/cdc_34351_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]