Heavy metals, organic solvents and multiple sclerosis: an exploratory look at gene-environment interactions

Details

• Alternative Title:
  Arch Environ Occup Health
• Personal Author:
  Napier, Melanie D. ; Poole, Charles ; Satten, Glen A. ; Ashley-Koch, Allison ; Marrie, Ruth Ann ; Williamson, Dhelia M.
• Description:
  Exposure to heavy metals and organic solvents are potential etiologic factors for multiple sclerosis (MS), but their interaction with MS-associated genes is under-studied. The authors explored the relationship between environmental exposure to lead, mercury, and solvents and 58 single-nucleotide polymorphisms (SNPs) in MS-associated genes. Data from a population-based case-control study of 217 prevalent MS cases and 496 age-, race-, gender-, and geographically matched controls were used to fit conditional logistic regression models of the association between the chemical, gene, and MS, adjusting for education and ancestry. MS cases were more likely than controls to report lead (odds ratio [OR] = 2.03; 95% confidence interval [CI]: 1.07, 3.86) and mercury exposure (OR = 2.06; 95% CI: 1.08, 3.91). Findings of potential gene-environment interactions between SNPs in TNF-α, TNF-β, TCA-β, VDR, MBP, and APOE, and lead, mercury, or solvents should be considered cautiously due to limited sample size.
• Subjects:
  Case-Control Studies Environmental Exposure Female Gene-Environment Interaction Heavy Metal Poisoning Humans Logistic Models Male Metals, Heavy Multiple Sclerosis Poisoning Polymorphism, Single Nucleotide Solvents

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• Keywords:
  Autoimmune Diseases Case-control Epidemiology Gene-environment Interaction Heavy Metal Exposure Organic Solvents Multiple Sclerosis
• Source:
  Arch Environ Occup Health. 71(1):26-34
• Pubmed ID:
  25137520
• Pubmed Central ID:
  PMC4334728
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/ ; P30 ES010126/ES/NIEHS NIH HHSUnited States/ ; 200-2003-01396/PHS HHSUnited States/
• Volume:
  71
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:0e56a017e6925a6796f14dcd762aa5b15cad8242b294b902e9a9a9e2fed4330b6f944f5eb378a23f170f9910ec2fc20b8b0f1533b8f97814089ab4417da3bf55
• Download URL:
  https://stacks.cdc.gov/view/cdc/30298/cdc_30298_DS1.pdf
• File Type:
  [PDF - 318.27 KB ]