Heavy metals, organic solvents and multiple sclerosis: an exploratory look at gene-environment interactions

Napier, Melanie D.; Poole, Charles; Satten, Glen A.; Ashley-Koch, Allison; Marrie, Ruth Ann; Williamson, Dhelia M.

doi:10.1080/19338244.2014.937381

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Heavy metals, organic solvents and multiple sclerosis: an exploratory look at gene-environment interactions

1 2 2016
By Napier, Melanie D. ; Poole, Charles ; Satten, Glen A. ; ...
http://dx.doi.org/10.1080/19338244.2014.937381
Source: Arch Environ Occup Health. 71(1):26-34

[PDF-318.27 KB]

English

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Details:

Alternative Title:

Arch Environ Occup Health
Personal Author:

Napier, Melanie D. ; Poole, Charles ; Satten, Glen A. ; Ashley-Koch, Allison ; Marrie, Ruth Ann ; ... More +

Napier, Melanie D. ; Poole, Charles ; Satten, Glen A. ; Ashley-Koch, Allison ; Marrie, Ruth Ann ; Williamson, Dhelia M. Less -
Description:

Exposure to heavy metals and organic solvents are potential etiologic factors for multiple sclerosis (MS), but their interaction with MS-associated genes is under-studied. The authors explored the relationship between environmental exposure to lead, mercury, and solvents and 58 single-nucleotide polymorphisms (SNPs) in MS-associated genes. Data from a population-based case-control study of 217 prevalent MS cases and 496 age-, race-, gender-, and geographically matched controls were used to fit conditional logistic regression models of the association between the chemical, gene, and MS, adjusting for education and ancestry. MS cases were more likely than controls to report lead (odds ratio [OR] = 2.03; 95% confidence interval [CI]: 1.07, 3.86) and mercury exposure (OR = 2.06; 95% CI: 1.08, 3.91). Findings of potential gene-environment interactions between SNPs in TNF-α, TNF-β, TCA-β, VDR, MBP, and APOE, and lead, mercury, or solvents should be considered cautiously due to limited sample size.
Subjects:

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Case-Control Studies Environmental Exposure Female Gene-Environment Interaction Heavy Metal Poisoning Humans Logistic Models Male Metals, Heavy Multiple Sclerosis Poisoning Polymorphism, Single Nucleotide Solvents
Keywords:

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Autoimmune Diseases Case-control Epidemiology Gene-environment Interaction Heavy Metal Exposure Organic Solvents Multiple Sclerosis
Source:

Arch Environ Occup Health. 71(1):26-34
Pubmed ID:

25137520
Pubmed Central ID:

PMC4334728
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/ ; P30 ES010126/ES/NIEHS NIH HHSUnited States/ ; 200-2003-01396/PHS HHSUnited States/

CC999999/Intramural CDC HHSUnited States/ ; P30 ES010126/ES/NIEHS NIH HHSUnited States/ ; 200-2003-01396/PHS HHSUnited States/ Less -
Volume:

71
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:30b1a6f8dcfce48a110e9a850e826c25ea13f616536c638ffb4a2700df717146
Download URL:

https://stacks.cdc.gov/view/cdc/30298/cdc_30298_DS1.pdf
File Type:

	NIHMS655955-supplement-Supplemental_Table_1.pdf	pdf
	NIHMS655955-supplement-Supplemental_Table_2.pdf	pdf
	NIHMS655955-supplement-Supplemental_Table_3.pdf	pdf
	nihms655955.nxml	xml

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