Occupational exposures among nurses and risk of spontaneous abortion

Details

• Alternative Title:
  Am J Obstet Gynecol
• Personal Author:
  LAWSON, Christina C ; ROCHELEAU, Carissa M. ; WHELAN, Elizabeth A ; LIVIDOTI HIBERT, Eileen N. ; GRAJEWSKI, Barbara ; SPIEGELMAN, Donna ; RICH-EDWARDS, Janet W.
• Description:
  Objective
  
  We investigated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents (disinfectants), and X-rays and the risk of spontaneous abortion in U.S. nurses.
  
  Study Design
  
  Pregnancy outcome and occupational exposures were collected retrospectively from 8,461 participants of the Nurses’ Health Study II. Of these, 7,482 were eligible for analysis using logistic regression.
  
  Results
  
  Participants reported 6,707 live births, and 775 (10%) spontaneous abortions (<20 weeks). After adjusting for age, parity, shift work, and hours worked, antineoplastic drug exposure was associated with a 2-fold increased risk of spontaneous abortion, particularly with early spontaneous abortion before the 12th week, and 3.5-fold increased risk among nulliparous women. Exposure to sterilizing agents was associated with a 2-fold increased risk of late spontaneous abortion (12–20 weeks), but not with early spontaneous abortion.
  
  Conclusion
  
  This study suggests that certain occupational exposures common to nurses are related to risks of spontaneous abortion.
  
  
• Subjects:
  Abortion, Spontaneous Adult Anesthetics, Inhalation Antineoplastic Agents Antiviral Agents Disinfectants Female Humans Nurses Occupational Exposure Pregnancy Pregnancy Outcome Prevalence Retrospective Studies Risk X-Rays

  More +
• Source:
  Am J Obstet Gynecol. 206(4):327.e1-327.e8.
• Pubmed ID:
  22304790
• Pubmed Central ID:
  PMC4572732
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  206
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:22523c7f39eabca094c82f89e93034b27a08968a960cbd22fc6336c0b8256318
• Download URL:
  https://stacks.cdc.gov/view/cdc/34341/cdc_34341_DS1.pdf
• File Type:
  [PDF - 222.38 KB ]