Occupational exposures among nurses and risk of spontaneous abortion

Details

• Personal Author:
  Grajewski, Barbara A. ; Lawson, Christina C. ; Lividoti Hibert EN ; Rich-Edwards JW ; Rocheleau CM ; Spiegelman D ; Whelan, Elizabeth A.
• Description:
  OBJECTIVE: We investigated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents (disinfectants), and X-rays and the risk of spontaneous abortion in US nurses. STUDY DESIGN: Pregnancy outcome and occupational exposures were collected retrospectively from 8461 participants of the Nurses' Health Study II. Of these, 7482 were eligible for analysis using logistic regression. RESULTS: Participants reported 6707 live births, and 775 (10%) spontaneous abortions (less than 20 weeks). After adjusting for age, parity, shift work, and hours worked, antineoplastic drug exposure was associated with a 2-fold increased risk of spontaneous abortion, particularly with early spontaneous abortion before the 12th week, and 3.5-fold increased risk among nulliparous women. Exposure to sterilizing agents was associated with a 2-fold increased risk of late spontaneous abortion (12-20 weeks), but not with early spontaneous abortion. CONCLUSION: This study suggests that certain occupational exposures common to nurses are related to risks of spontaneous abortion. Description provided by NIOSH
• Subjects:
  • Anesthesia
  • Antineoplastic Agents
  • Disinfectants
  • Environmental Monitoring
  • Hazardous Substances
  • Health Personnel
  • Occupational Health
  • Pregnancy
  • Risk Assessment
  • Safety
  More +
• Keywords:
  • Biohazards
  • Drugs
  • Health-care-personnel
  • Mathematical-models
  • Pregnancy
  • Reproductive-effects
  • Reproductive-hazards
  • Reproductive-system
  • Reproductive-system-disorders
  • Risk-analysis
  More +
• ISSN:
  0002-9378
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Ohio ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  206
• Issue:
  4
• NIOSHTIC Number:
  nn:20040297
• Citation:
  Am J Obstet Gynecol 2012 Apr; 206(4):327.e1-327.e8
• Contact Point Address:
  Christina C. Lawson, PhD, CDC/NIOSH, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226
• Email:
  clawson@cdc.gov
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Healthcare and Social Assistance
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Obstetrics and Gynecology
• Download URL:
  https://stacks.cdc.gov/view/cdc/193229/cdc_193229_DS1.pdf
• File Type:
  [PDF - 304.90 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5609f1d776dcdd221e89eff35d733f2d843d002370c79e675390f80dcd374d51de4b6b3a96859b36da38c49f9f828261cf5403cb0a93e09f22c709e794a7c86f