Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Yucesoy, Berran ; Johnson, Victor J. ; Lummus, Zana L. ; Kashon, Michael L. ; Rao, Marepalli ; Bannerman-Thompson, Hansen ; Frye, Bonnie ; Wang, Wei ; Gautrin, Denyse ; Cartier, André ; Boulet, Louis-Philippe ; Sastre, Joaquin ; Quirce, Santiago ; Tarlo, Susan M. ; Germolec, Dori R. ; Luster, Michael I. ; Bernstein, David I.
• Description:
  Objective
  
  To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA).
  
  Methods
  
  The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels.
  
  Results
  
  The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively).
  
  Conclusion
  
  These results suggest that genetic variations within HLA genes play a role in DA risk.
  
  
• Subjects:
  Adult Article Asthma Female Genes, MHC Class I Genes, MHC Class II Genetic Variation Genotype Humans Isocyanates Male Occupational Diseases Occupational Exposure Polymorphism, Single Nucleotide Risk

  More +
• Source:
  J Occup Environ Med. 56(4):382-387.
• Pubmed ID:
  24709764
• Pubmed Central ID:
  PMC4572490
• Document Type:
  Journal Article
• Funding:
  R01 OH 008795/OH/NIOSH CDC HHS/United States ; XCC2/Intramural CDC HHS/United States ; Y1-ES0001/ES/NIEHS NIH HHS/United States
• Volume:
  56
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cd73c393101aa1cf022df0d6d38fa870d5b13f09eef7104e8785a1ac816b573a
• Download URL:
  https://stacks.cdc.gov/view/cdc/34338/cdc_34338_DS1.pdf
• File Type:
  [PDF - 194.18 KB ]