Lung function, 25-hydroxyvitamin D concentrations and mortality in US adults

Details

• Alternative Title:
  Eur J Clin Nutr
• Personal Author:
  Ford, ES
• Description:
  OBJECTIVE ; To explore the associations between serum concentrations of vitamin D (25(OH)D) and all-cause mortality among US adults defined by lung function (LF) status, particularly among adults with obstructive LF (OLF). ; METHODS ; Data from 10 795 adults aged 20–79 years (685 with restrictive LF (RLF) and 1309 with OLF) who participated in the Third National Health and Nutrition Examination Survey (1988–1994), had a spirometric examination, and were followed through 2006 were included. ; RESULTS ; During 14.2 years of follow-up, 1792 participants died. Mean adjusted concentrations of 25(OH)D were 75.0 nmol/l (s.e. 0.7) for adults with normal LF (NLF), 70.4 nmol/l (s.e. 1.8) for adults with RLF, 75.5 nmol/l (s.e. 1.5) for adults with mild obstruction and 71.0 nmol/l (s.e. 1.9) among adults with moderate or worse obstruction (P = 0.030). After adjustment for sociodemographic factors, lifestyle factors, clinical variables and prevalent chronic conditions, a concentration of <25 nmol/l compared with ≥75 nmol//l was associated with mortality only among adults with NLF (hazard ratio (HR) 1.76; 95% confidence interval (CI) 1.03, 3.00). Among participants with OLF, adjusted HRs were 0.65 (95% CI 0.29, 1.48), 1.21 (95% CI 0.89, 1.66) and 0.97 (95% CI 0.78, 1.19) among those with concentrations <25, 25–<50 and 50–<75 nmol/l, respectively. ; CONCLUSIONS ; Baseline concentrations of 25(OH)D did not significantly predict mortality among US adults with impaired LF.
• Keywords:
  • Adult
  • Aged
  • Aging
  • Cause of Death
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Lung Diseases, Obstructive
  • Male
  More +
• Source:
  Eur J Clin Nutr. 69(5):572-578
• Pubmed ID:
  25118000
• Pubmed Central ID:
  PMC4570480
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  69
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/34329/cdc_34329_DS1.pdf
• File Type:
  [PDF - 261.58 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4115bd9f1fa1e30a863213342c990f358200c85e19601343e1571d87ad17e1e1