Lung function, 25-hydroxyvitamin D concentrations and mortality in US adults

Details

• Alternative Title:
  Eur J Clin Nutr
• Personal Author:
  Ford, ES
• Description:
  OBJECTIVE
  
  To explore the associations between serum concentrations of vitamin D (25(OH)D) and all-cause mortality among US adults defined by lung function (LF) status, particularly among adults with obstructive LF (OLF).
  
  METHODS
  
  Data from 10 795 adults aged 20–79 years (685 with restrictive LF (RLF) and 1309 with OLF) who participated in the Third National Health and Nutrition Examination Survey (1988–1994), had a spirometric examination, and were followed through 2006 were included.
  
  RESULTS
  
  During 14.2 years of follow-up, 1792 participants died. Mean adjusted concentrations of 25(OH)D were 75.0 nmol/l (s.e. 0.7) for adults with normal LF (NLF), 70.4 nmol/l (s.e. 1.8) for adults with RLF, 75.5 nmol/l (s.e. 1.5) for adults with mild obstruction and 71.0 nmol/l (s.e. 1.9) among adults with moderate or worse obstruction (P = 0.030). After adjustment for sociodemographic factors, lifestyle factors, clinical variables and prevalent chronic conditions, a concentration of <25 nmol/l compared with ≥75 nmol//l was associated with mortality only among adults with NLF (hazard ratio (HR) 1.76; 95% confidence interval (CI) 1.03, 3.00). Among participants with OLF, adjusted HRs were 0.65 (95% CI 0.29, 1.48), 1.21 (95% CI 0.89, 1.66) and 0.97 (95% CI 0.78, 1.19) among those with concentrations <25, 25–<50 and 50–<75 nmol/l, respectively.
  
  CONCLUSIONS
  
  Baseline concentrations of 25(OH)D did not significantly predict mortality among US adults with impaired LF.
  
  
• Keywords:
  Adult Aged Aging Cause Of Death Female Follow-Up Studies Humans Incidence Lung Diseases, Obstructive Male Middle Aged Nutrition Surveys Predictive Value Of Tests Respiratory Function Tests Risk Factors United States Vitamin D Vitamin D Deficiency Young Adult

  More +
• Source:
  Eur J Clin Nutr. 69(5):572-578
• Pubmed ID:
  25118000
• Pubmed Central ID:
  PMC4570480
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  69
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4115bd9f1fa1e30a863213342c990f358200c85e19601343e1571d87ad17e1e1
• Download URL:
  https://stacks.cdc.gov/view/cdc/34329/cdc_34329_DS1.pdf
• File Type:
  [PDF - 261.58 KB ]