Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study

Details

• Alternative Title:
  BMC Neurol
• Personal Author:
  Reeves, William C ; Heim, Christine ; Maloney, Elizabeth M ; Youngblood, Laura Solomon ; Unger, Elizabeth R ; Decker, Michael J ; Jones, James F ; Rye, David B
• Description:
  Background ; The etiology and pathophysiology of chronic fatigue syndrome (CFS) remain inchoate. Attempts to elucidate the pathophysiology must consider sleep physiology, as unrefreshing sleep is the most commonly reported of the 8 case-defining symptoms of CFS. Although published studies have consistently reported inefficient sleep and documented a variable occurrence of previously undiagnosed primary sleep disorders, they have not identified characteristic disturbances in sleep architecture or a distinctive pattern of polysomnographic abnormalities associated with CFS. ; Methods ; This study recruited CFS cases and non-fatigued controls from a population based study of CFS in Wichita, Kansas. Participants spent two nights in the research unit of a local hospital and underwent overnight polysomnographic and daytime multiple sleep latency testing in order to characterize sleep architecture. ; Results ; Approximately 18% of persons with CFS and 7% of asymptomatic controls were diagnosed with severe primary sleep disorders and were excluded from further analysis. These rates were not significantly different. Persons with CFS had a significantly higher mean frequency of obstructive apnea per hour (p = .003); however, the difference was not clinically meaningful. Other characteristics of sleep architecture did not differ between persons with CFS and controls. ; Conclusion ; Although disordered breathing during sleep may be associated with CFS, this study generally did not provide evidence that altered sleep architecture is a critical factor in CFS. Future studies should further scrutinize the relationship between subjective sleep quality relative to objective polysomnographic measures.
• Subjects:
  • Case-Control Studies
  • Community Health Planning
  • Electroencephalography
  • Electromyography
  • Fatigue Syndrome, Chronic
  • Female
  • Humans
  • Male
  • Middle Aged
  • Narcolepsy
  More +
• Source:
  BMC Neurol. 2006; 6:41.
• Document Type:
  Journal Article
• Volume:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/3417/cdc_3417_DS1.pdf
• File Type:
  [PDF - 259.43 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:19b39388f4910e255aa4e956a30841d63c823ecffde6af16ee567f5a0f38264957c2772e468b1d5edbc4fffce500d2a86188e94b2c7da2a2c0b8deedfb1be645