Population attributable fractions for three perinatal risk factors for autism spectrum disorders, 2002 and 2008 autism and developmental disabilities monitoring network

Details

• Alternative Title:
  Ann Epidemiol
• Personal Author:
  Schieve, Laura A. ; Tian, Lin H. ; Baio, Jon ; Rankin, Kristin ; Rosenberg, Deborah ; Wiggins, Lisa ; Maenner, Matthew J. ; Yeargin-Allsopp, Marshalyn ; Durkin, Maureen ; Rice, Catherine ; King, Lydia ; Kirby, Russell S. ; Wingate, Martha S. ; Devine, Owen
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• Description:
  Purpose ; Numerous studies establish associations between adverse perinatal outcomes/complications and autism spectrum disorder (ASD). There has been little assessment of population attributable fractions (PAFs). ; Methods ; We estimated average ASD PAFs for preterm birth (PTB), small for gestational age (SGA), and Cesarean delivery (CD) in a U.S. population. Average PAF methodology accounts for risk factor co-occurrence. ASD cases were singleton non-Hispanic white, non-Hispanic black, and Hispanic children born in 1994 (n = 703) or 2000 (n = 1339) who resided in 48 U.S. counties included within eight Autism and Developmental Disabilities Monitoring Network sites. Cases were matched on birth year, sex, and maternal county of residence, race-ethnicity, age, and education to 20 controls from U.S. natality files. Results: For the 1994 cohort, average PAFs were 4.2%, 0.9%, and 7.9% for PTB, SGA, and CD, respectively. The summary PAF was 13.0% (1.7%–19.5%). For the 2000 cohort, average PAFs were 2.0%, 3.1%, and 6.7% for PTB, SGA, and CD, respectively, with a summary PAF of 11.8% (7.5%–15.9%). ; Conclusions ; Three perinatal risk factors notably contribute to ASD risk in a U.S. population. Because each factor represents multiple etiologic pathways, PAF estimates are best interpreted as the proportion of ASD attributable to having a suboptimal perinatal environment resulting in PTB, SGA, and/or CD.
• Subjects:
  • Adult
  • Birth Weight
  • Cesarean Section
  • Child Development Disorders, Pervasive
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Male
  • Perinatal Care
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• Source:
  Ann Epidemiol. 24(4):260-266.
• Pubmed ID:
  24529515
• Pubmed Central ID:
  PMC4562459
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  24
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/34144/cdc_34144_DS1.pdf
• File Type:
  [PDF - 320.63 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6b78b44878e73d310b49fc98a3b7c4eb36a9e54a688f1a0357291f905dac92dc