Evaluation of Ricinine, a Ricin Biomarker, from a Non-Lethal Castor Bean Ingestion

Details

• Alternative Title:
  J Anal Toxicol
• Personal Author:
  Hamelin, Elizabeth I. ; Johnson, Rudolph C. ; Osterloh, John ; Thomas, Jerry
• Description:
  A case is presented of the attempted suicide of a 58-year-old man using castor beans. The patient came to the emergency room complaining of nausea, vomiting and diarrhea for nine hours following the ingestion of six castor beans. Urine samples were taken throughout the hospital stay and submitted to the Centers for Disease Control and Prevention for analysis of ricinine, a castor bean component. The samples were found to be positive for ricinine, with a maximum concentration of 674 µg/g-creatinine excreted approximately 23 h post-exposure. Subsequent samples demonstrated lower ricinine concentrations, with the final sample taken at 62 h post-exposure at a concentration of 135 µg/g-creatinine of ricinine. The estimated urinary excretion half-life was approximately 15 h and the recovery of ricinine in the urine over the three days was estimated to be less than 10%. The patient fully recovered with supportive care and was discharged from the hospital six days after admission.
• Subjects:
  Alkaloids Biomarkers Castor Bean Diarrhea Half-Life Humans Male Middle Aged Pyridones Ricin Suicide, Attempted Treatment Outcome Vomiting

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• Source:
  J Anal Toxicol. 36(9):660-662.
• Pubmed ID:
  23014889
• Pubmed Central ID:
  PMC4561852
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  36
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c37f44eadfad95c8941dc2cad114467ed077c4dec4774bda1a7b8cd083e196c0
• Download URL:
  https://stacks.cdc.gov/view/cdc/34125/cdc_34125_DS1.pdf
• File Type:
  [PDF - 401.67 KB ]