Associations between antioxidants and all-cause mortality among US adults with obstructive lung function

Ford, Earl S.; Li, Chaoyang; Cunningham, Timothy J.; Croft, Janet B.

doi:10.1017/S0007114514002669

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Associations between antioxidants and all-cause mortality among US adults with obstructive lung function

11 28 2014
By Ford, Earl S. ; Li, Chaoyang ; Cunningham, Timothy J. ; ...
http://dx.doi.org/10.1017/S0007114514002669
Source: Br J Nutr. 112(10):1662-1673

[PDF-581.88 KB]

English

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Details:

Alternative Title:

Br J Nutr
Personal Author:

Ford, Earl S. ; Li, Chaoyang ; Cunningham, Timothy J. ; Croft, Janet B.

Ford, Earl S. ; Li, Chaoyang ; Cunningham, Timothy J. ; Croft, Janet B. Less -
Description:

Chronic obstructive pulmonary disease is characterised by oxidative stress, but little is known about the associations between antioxidant status and all-cause mortality in adults with this disease. The objective of the present study was to examine the prospective associations between concentrations of α- and β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene, Se, vitamin C and α-tocopherol and all-cause mortality among US adults with obstructive lung function. Data collected from 1492 adults aged 20-79 years with obstructive lung function in the National Health and Nutrition Examination Survey III (1988-94) were used. Through 2006, 629 deaths were identified during a median follow-up period of 14 years. After adjustment for demographic variables, the concentrations of the following antioxidants modelled as continuous variables were found to be inversely associated with all-cause mortality among adults with obstructive lung function: α-carotene (P= 0·037); β-carotene (P= 0·022); cryptoxanthin (P= 0·022); lutein/zeaxanthin (P= 0·004); total carotenoids (P= 0·001); vitamin C (P< 0·001). In maximally adjusted models, only the concentrations of lycopene (P= 0·013) and vitamin C (P= 0·046) were found to be significantly and inversely associated with all-cause mortality. No effect modification by sex was detected, but the association between lutein/zeaxanthin concentrations and all-cause mortality varied by smoking status (P interaction= 0·048). The concentrations of lycopene and vitamin C were inversely associated with all-cause mortality in this cohort of adults with obstructive lung function.
Subjects:

[+]

Adult Aged Antioxidants Ascorbic Acid Carotenoids Cause Of Death Female Humans Lung Male Middle Aged Oxidative Stress Prospective Studies Pulmonary Disease, Chronic Obstructive Smoking Young Adult
Keywords:

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Chronic Obstructive Pulmonary Disease Mortality
Source:

Br J Nutr. 112(10):1662-1673
Pubmed ID:

25315508
Pubmed Central ID:

PMC4560207
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/
Place as Subject:

United States
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:87c387e8c06c5d9af8900bbd14c748706947f5db4641887ebb365151912ac0a2
Download URL:

https://stacks.cdc.gov/view/cdc/34081/cdc_34081_DS1.pdf
File Type:

nihms-718758.nxml

xml

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