Brainstem auditory evoked potentials in children with low level cumulative lead exposure

Details

• Alternative Title:
  Braz J Otorhinolaryngol
• Personal Author:
  Alvarenga, Kátia F. ; Morata, Thais C. ; Lopes, Andréa Cintra ; Feniman, Mariza Ribeiro ; Corteletti, Lilian Cássia Bórnia Jacob
• Description:
  Introduction
  
  Earlier studies have demonstrated an auditory effect of lead exposure in children,but information on the effects of low chronic exposures needs to be further elucidated.
  
  Objective
  
  To investigate the effect of low chronic exposures of the auditory system in childrenwith a history of low blood lead levels, using an auditory electrophysiological test.
  
  Methods
  
  Contemporary cross-sectional cohort. Study participants underwent tympanometry, pure tone and speech audiometry, transient evoked otoacoustic emissions, and brainstem auditory evoked potentials, with blood lead monitoring over a period of 35.5 months. The study included 130 children, with ages ranging from 18 months to 14 years, 5 months (mean age 6years, 8 months ± 3 years, 2 months).
  
  Results
  
  The mean time-integrated cumulative blood lead index was 12 g/dL (SD ± 5.7, range:2.433). All participants had hearing thresholds equal to or below 20 dBHL and normal amplitudes of transient evoked otoacoustic emissions. No association was found between the absolute latencies of waves I, III, and V, the interpeak latencies I---III, III---V, and I---V, and the cumulative lead values.
  
  Conclusion
  
  No evidence of toxic effects from chronic low lead exposures was observed on the auditory function of children living in a lead contaminated area.
  
  
• Subjects:
  Article Auditory Brainstem Response Lead Contamination Ototoxicity Pure-tone Audiometry
• Source:
  Braz J Otorhinolaryngol. 81(1):37-43.
• Pubmed ID:
  25458254
• Pubmed Central ID:
  PMC4557785
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  81
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c4106d04f9e0d820616ab5431827250e5641f02f26192792cace52e76dd34af440233d6e994c47c02fa252c1a043585876453ca066e3acf92f79cbdd0674757a
• Download URL:
  https://stacks.cdc.gov/view/cdc/34049/cdc_34049_DS1.pdf
• File Type:
  [PDF - 419.65 KB ]