Brainstem auditory evoked potentials in children with lead exposure

Details

• Personal Author:
  Alvarenga KF ; Corteletti LC ; Feniman MR ; Lopes AC ; Morata, Thais C.
• Description:
  Introduction: Earlier studies have demonstrated an auditory effect of lead exposure in children, but information on the effects of low chronic exposures needs to be further elucidated. Objective: To investigate the effect of low chronic exposures of the auditory system in children with a history of low blood lead levels, using an auditory electrophysiological test. Methods: Contemporary cross-sectional cohort. Study participants underwent tympanometry, pure tone and speech audiometry, transient evoked otoacoustic emissions, and brainstem auditory evoked potentials, with blood lead monitoring over a period of 35.5 months. The study included 130 children, with ages ranging from 18 months to 14 years, 5 months (mean age 6 years, 8 months +/- 3 years, 2 months). Results: The mean time-integrated cumulative blood lead index was 12 microg/dL (SD +/- 5.7, range: 2.433). All participants had hearing thresholds equal to or below 20 dBHL and normal amplitudes of transient evoked otoacoustic emissions. No association was found between the absolute latencies of waves I, III, and V, the interpeak latencies I---III, III---V, and I---V, and the cumulative lead values. Conclusion: No evidence of toxic effects from chronic low lead exposures was observed on the auditory function of children living in a lead contaminated area. [Description provided by NIOSH]
• Subjects:
  Electrophysiology Environmental Monitoring Hearing Hematologic Tests Lead Lead Poisoning Noise Occupational Exposure Occupational Health Poisoning Safety Sense Organs

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• Keywords:
  Acoustics Audiological-testing Audiometry Auditory-system Author Keywords: Toxicity Biological-effects Biological-monitoring Blood-sampling Brainstem Auditory Evoked Potentials Children Chronic-exposure Electrophysiological-examinations Exposure-assessment Hearing-threshold Lead-compounds Lead Poisoning Pure-tone Audiometry

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• ISSN:
  1808-8694
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  37-43
• Volume:
  81
• Issue:
  1
• NIOSHTIC Number:
  nn:20045354
• Citation:
  Braz J Otorhinolaryngol 2015 Jan-Feb; 81(1):37-43
• Contact Point Address:
  Lilian Cassia Bornia Jacob Cortelettia, Department of Speech Therapy and Audiology, Faculdade de Odontologia de Bauru, Universidade de São Paulo (FOB-USP), Bauru, SP, Brazil
• Email:
  lilianjacob@fob.usp.br
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Manufacturing ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Brazilian Journal of Otorhinolaryngology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d3c2648215d16a228ecdf796cf50798948a4afd4f282a1a7e09dce717bd00aae5cd5326cd5b66b436e005c2d70b0e7916de3dd2e33f6dcf542b99cda3ff00671
• Download URL:
  https://stacks.cdc.gov/view/cdc/200804/cdc_200804_DS1.pdf
• File Type:
  [PDF - 527.00 KB ]