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Stabilities of hemoglobins A and S in dried blood spots stored under controlled conditions
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May 20 2013
Source: Clin Biochem. 46(12):1089-1092. -
Alternative Title:Clin Biochem
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Personal Author:
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Description:Objective
We aimed to measure separately the contributions of heat and humidity to changes in levels of hemoglobins A and S in dried-blood-spot (DBS) samples.
Design and methods
We stored paired sets of DBSs at 37 °C for predetermined intervals in low-humidity and high-humidity environments. Hemoglobin A and S levels of all samples in each complete set were measured in a single high performance liquid chromatography run.
Results
During the one-month storage intervals, both hemoglobin species lost about 35% of initial levels in low-humidity storage and almost all of initial levels in high-humidity storage.
Conclusions
Minimizing both humidity and temperature in the transportation and storage environments of DBS samples is essential to maintaining the integrity of the hemoglobin tetramer molecules.
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Pubmed ID:23701845
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Pubmed Central ID:PMC4557610
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