Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the National Birth Defects Prevention Study

Details

• Personal Author:
  Agopian AJ ; Correa A ; Desrosiers TA ; Gilboa SM ; Langlois PH ; Lawson, Christina C. ; Lee LJ ; Lupo PJ ; Malik S ; Mitchell LE ; Romitti PA ; Shaw GM ; Symanski, Elaine ; Waters MA
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  BACKGROUND: There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. METHODS: Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring. RESULTS: The prevalence of occupational PAH exposure was 4.0% in CHD case mothers (76/1907) and 3.6% in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95% confidence interval [CI], 0.58-1.67), septal defects (AOR, 1.28; 95% CI, 0.86-1.90), or with any isolated CHD subtype. CONCLUSIONS: Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population-based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Epidemiology Hydrocarbons Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Pregnancy Safety
• Keywords:
  Author Keywords: Birth Defects Birth Defects Cardiovascular-disease Cardiovascular-function Cardiovascular-system Cardiovascular-system-disease Cardiovascular-system-disorders Case Control Studies Children Congenital-effects Congenital Heart Defects Exposure-levels Heart Humans Maternal Occupation Models Occupational Exposure Polycyclic-aromatic-hydrocarbons Polycyclic Aromatic Hydrocarbons Population Based Studies Prenatal-exposure Regression Analysis

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• ISSN:
  1542-0752
• Document Type:
  Text
• Funding:
  Contract ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; California ; Georgia ; Iowa ; Mississippi ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 7 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  94
• Issue:
  11
• NIOSHTIC Number:
  nn:20041945
• Citation:
  Birth Defects Res A Clin Mol Teratol 2012 Nov; 94(11):875-881
• Contact Point Address:
  Philip J. Lupo, University of Texas School of Public Health, 1200 Herman Pressler Drive, RAS 511, Houston, TX 77030
• Email:
  Philip.J.Lupo@uth.tmc.edu
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Battelle
• Peer Reviewed:
  True
• Start Date:
  20011001
• Source Full Name:
  Birth Defects Research Part A: Clinical and Molecular Teratology
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8a00dcd13e3acf2ff09b109c9bb1556ba195ff86b182068988cafd1f55864953891e87e58c60a37cd60b80b6eaafffafb2133368521eb695425e4c3f7114189c
• Download URL:
  https://stacks.cdc.gov/view/cdc/194345/cdc_194345_DS1.pdf
• File Type:
  [PDF - 86.95 KB ]