Details:

Alternative Title:
Genet Med
Publisher's site:
http://dx.doi.org/10.1038/gim.2012.93
Personal Author:
Zhu, Jin Liang ; Hasle, Henrik ; Correa, Adolfo ; Schendel, Diana ; Friedman, J.M. ; ... More +
Zhu, Jin Liang ; Hasle, Henrik ; Correa, Adolfo ; Schendel, Diana ; Friedman, J.M. ; Olsen, Jørn ; Rasmussen, Sonja A. ; Less -
Description:
Purpose Several studies have shown substantially longer survival among persons with Down syndrome in recent decades. We examined survival patterns among Danish persons with Down syndrome by karyotype. Methods A national cohort of 3,530 persons with Down syndrome identified from the Danish Cytogenetic Register and a reference cohort of persons without Down syndrome randomly selected from the general population were followed from 1 April 1968 to 15 January 2009 by linkages to the Register of Causes of Death and the Civil Registration System. Results Overall, persons with Down syndrome had higher mortality than the reference cohort but to a lesser degree for persons with mosaic trisomy 21 than for persons with standard trisomy 21 or with Robertsonian translocations (hazard ratio 4.98 (95% confidence interval 3.51–7.08), 8.94 (8.32–9.60), and 10.23 (7.50–13.97), respectively). Among persons with Down syndrome born after April 1968, more recent birth cohorts had lower mortality rates than older birth cohorts, which was largely due to declining mortality among persons with Down syndrome who also had congenital heart defects. Conclusion Recent birth cohorts of persons with Down syndrome experienced declining mortality, likely due to treatment for congenital heart defects, and persons with mosaic trisomy 21 had better survival than persons with other Down syndrome karyotypes.
Subject:
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Adolescent
Adult
Article
Cause Of Death
Child
Child, Preschool
Congenital Heart Defects
Denmark
Down Syndrome
Female
Heart Defects, Congenital
Humans
Karyotype
Male
Mortality
Mosaic Trisomy 21
Registries
Survival
Young Adult

Source:
Genet Med. 15(1):64-69.
Pubmed ID:
22878506
Pubmed Central ID:
PMC4532298
Document Type:
Journal Article ;
Funding:
5 U10 DD000230-06/DD/NCBDD CDC HHS/United States ; AVU3/Intramural CDC HHS/United States ;
5 U10 DD000230-06/DD/NCBDD CDC HHS/United States ; AVU3/Intramural CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:28f81565c3f46044bfb1f85c4fe976d5428f18cb6e5885d0936b435929ec0fb9
File Type:

Supporting Files

• 	NIHMS712636-supplement-Supp_Table_1.pdf	pdf
  	NIHMS712636-supplement-Supp_Table_2.pdf	pdf
  	nihms712636.nxml	txt
  	nihms712636f1.gif	gif
  	nihms712636f1.jpg	jpeg

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