Effectiveness of practices to reduce blood culture contamination: A Laboratory Medicine Best Practices systematic review and meta-analysis☆
Published Date:Jun 16 2012
Source:Clin Biochem. 2012; 45(0):999-1011.
Blood Specimen Collection/methods/standards
Cell Culture Techniques
Centers For Disease Control And Prevention (U.S.)
Comparative Effectiveness Research
False Positive Reactions
Healthcare Quality Improvement
Practice Guidelines As Topic
Reagent Kits, Diagnostic
Pubmed Central ID:PMC4518453
Funding:CC999999/Intramural CDC HHS/United States
W911NF-07-D-0001/DO 0191/TCN 07235/PHS HHS/United States
This article is a systematic review of the effectiveness of three practices for reducing blood culture contamination rates: venipuncture, phlebotomy teams, and prepackaged preparation/collection (prep) kits.
Design and methods
The CDC-funded Laboratory Medicine Best Practices Initiative systematic review methods for quality improvement practices were used.
Studies included as evidence were: 9 venipuncture (vs. versus intravenous catheter), 5 phlebotomy team; and 7 prep kit. All studies for venipuncture and phlebotomy teams favored these practices, with meta-analysis mean odds ratios for venipuncture of 2.69 and phlebotomy teams of 2.58. For prep kits 6 studies’ effect sizes were not statistically significantly different from no effect (meta-analysis mean odds ratio 1.12).
Venipuncture and the use of phlebotomy teams are effective practices for reducing blood culture contamination rates in diverse hospital settings and are recommended as evidence-based “best practices” with high overall strength of evidence and substantial effect size ratings. No recommendation is made for or against prep kits based on uncertain improvement.
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