Effectiveness of practices to reduce blood culture contamination: A Laboratory Medicine Best Practices systematic review and meta-analysis☆

Details

• Alternative Title:
  Clin Biochem
• Personal Author:
  Snyder, Susan R. ; Favoretto, Alessandra M. ; Baetz, Rich Ann ; Derzon, James H. ; Madison, Bereneice M. ; Mass, Diana ; Shaw, Colleen S. ; Layfield, Christopher D. ; Christenson, Robert H. ; Liebow, Edward B.
• Description:
  Objectives
  
  This article is a systematic review of the effectiveness of three practices for reducing blood culture contamination rates: venipuncture, phlebotomy teams, and prepackaged preparation/collection (prep) kits.
  
  Design and methods
  
  The CDC-funded Laboratory Medicine Best Practices Initiative systematic review methods for quality improvement practices were used.
  
  Results
  
  Studies included as evidence were: 9 venipuncture (vs. versus intravenous catheter), 5 phlebotomy team; and 7 prep kit. All studies for venipuncture and phlebotomy teams favored these practices, with meta-analysis mean odds ratios for venipuncture of 2.69 and phlebotomy teams of 2.58. For prep kits 6 studies’ effect sizes were not statistically significantly different from no effect (meta-analysis mean odds ratio 1.12).
  
  Conclusions
  
  Venipuncture and the use of phlebotomy teams are effective practices for reducing blood culture contamination rates in diverse hospital settings and are recommended as evidence-based “best practices” with high overall strength of evidence and substantial effect size ratings. No recommendation is made for or against prep kits based on uncertain improvement.
• Keywords:
  • Bacterial infections/diagnosis
  • Blood culture
  • Blood specimen collection/methods/standards
  • Comparative effectiveness research
  • Contamination
  • False positive reactions
  • Healthcare quality improvement
  • Laboratory medicine
  • Phlebotomy
  • Practice guideline
  More +
• Source:
  Clin Biochem. 2012; 45(0):999-1011
• Pubmed ID:
  22709932
• Pubmed Central ID:
  PMC4518453
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/ ; ImNIH/Intramural NIH HHSUnited States/ ; W911NF-07-D-0001/DO 0191/TCN 07235/PHS HHSUnited States/
• Volume:
  45
• Issue:
  0
• Download URL:
  https://stacks.cdc.gov/view/cdc/33833/cdc_33833_DS1.pdf
• File Type:
  [PDF - 1.10 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eba63f80c852b1bd08846d5fddbc456ded9f62d22d6dd6fef4c032730d113a02