Effectiveness of practices to reduce blood culture contamination: A Laboratory Medicine Best Practices systematic review and meta-analysis☆

Details

• Alternative Title:
  Clin Biochem
• Personal Author:
  Snyder, Susan R. ; Favoretto, Alessandra M. ; Baetz, Rich Ann ; Derzon, James H. ; Madison, Bereneice M. ; Mass, Diana ; Shaw, Colleen S. ; Layfield, Christopher D. ; Christenson, Robert H. ; Liebow, Edward B.
• Description:
  Objectives ; This article is a systematic review of the effectiveness of three practices for reducing blood culture contamination rates: venipuncture, phlebotomy teams, and prepackaged preparation/collection (prep) kits. ; Design and methods ; The CDC-funded Laboratory Medicine Best Practices Initiative systematic review methods for quality improvement practices were used. ; Results ; Studies included as evidence were: 9 venipuncture (vs. versus intravenous catheter), 5 phlebotomy team; and 7 prep kit. All studies for venipuncture and phlebotomy teams favored these practices, with meta-analysis mean odds ratios for venipuncture of 2.69 and phlebotomy teams of 2.58. For prep kits 6 studies’ effect sizes were not statistically significantly different from no effect (meta-analysis mean odds ratio 1.12). ; Conclusions ; Venipuncture and the use of phlebotomy teams are effective practices for reducing blood culture contamination rates in diverse hospital settings and are recommended as evidence-based “best practices” with high overall strength of evidence and substantial effect size ratings. No recommendation is made for or against prep kits based on uncertain improvement.
• Keywords:
  • Bacterial infections/diagnosis
  • Blood culture
  • Blood specimen collection/methods/standards
  • Comparative effectiveness research
  • Contamination
  • False positive reactions
  • Healthcare quality improvement
  • Laboratory medicine
  • Phlebotomy
  • Practice guideline
  More +
• Source:
  Clin Biochem. 2012; 45(0):999-1011
• Pubmed ID:
  22709932
• Pubmed Central ID:
  PMC4518453
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/ ; ImNIH/Intramural NIH HHSUnited States/ ; W911NF-07-D-0001/DO 0191/TCN 07235/PHS HHSUnited States/
• Volume:
  45
• Issue:
  0
• Download URL:
  https://stacks.cdc.gov/view/cdc/33833/cdc_33833_DS1.pdf
• File Type:
  [PDF - 1.10 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eba63f80c852b1bd08846d5fddbc456ded9f62d22d6dd6fef4c032730d113a02