Diabetic retinopathy in the SEARCH for Diabetes in Youth Cohort: a pilot study

Details

• Alternative Title:
  Diabet Med
• Personal Author:
  Mayer-Davis, E. J. ; Davis, C. ; Saadine, J. ; D'Agostino, R. B. ; Dabelea, D. ; Dolan, L. ; Garg, S. ; Lawrence, J. M. ; Pihoker, C. ; Rodriguez, B. L. ; Klein, B. E. ; Klein, R.
• Corporate Authors:
  SEARCH for Diabetes in Youth Study Group
• Description:
  Aims
  
  The aim of this pilot study was to generate an initial estimate of the prevalence and correlates of diabetic retinopathy in a racially and ethnically diverse sample of youth with Type 1 and Type 2 diabetes mellitus.
  
  Methods
  
  A pilot study was conducted among 222 individuals with Type 1 diabetes (79% non-Hispanic white, 21% other) and 43 with Type 2 diabetes (28% non-Hispanic white, 72% other), all of > 5 years duration (mean duration 6.8 years) who participated in the SEARCH for Diabetes in Youth study. Diabetic retinopathy was assessed using non-mydriatic retinal photography of both eyes.
  
  Results
  
  The prevalence of diabetic retinopathy was 17% for Type 1 diabetes and 42% for Type 2 diabetes (odds ratio 1.50, 95% CI 0.58–3.88; P = 0.40 adjusted for age, duration, gender, race/ethnicity, parental education and HbA1c. HbA1c was significantly higher among those with any diabetic retinopathy (adjusted mean 79 mmol/mol, 9.4%) vs. no diabetic retinopathy (adjusted mean 70 mmol/mol, 8.6%) (P = 0.015). LDL cholesterol was also significantly higher among those with any diabetic retinopathy (adjusted mean 107.2 mg/dl) compared with those without diabetic retinopathy (adjusted mean 97.9 mg/dl) (P = 0.04).
  
  Conclusions
  
  The prevalence of diabetic retinopathy in contemporary young individuals was substantial, particularly among minority youth and those with Type 2 diabetes. Further long-term study of diabetic retinopathy in youth is needed.
  
  
• Subjects:
  Adolescent Child Cohort Studies Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetic Retinopathy Humans Minority Groups Pilot Projects Prevalence White People Young Adult

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• Source:
  Diabet Med. 2012; 29(9):1148-1152.
• Pubmed ID:
  22269205
• Pubmed Central ID:
  PMC4495729
• Document Type:
  Journal Article
• Funding:
  1UL1RR026314-01/RR/NCRR NIH HHS/United States ; DP-05-069/DP/NCCDPHP CDC HHS/United States ; DP-10-001/DP/NCCDPHP CDC HHS/United States ; M01 RR00069/RR/NCRR NIH HHS/United States ; M01 RR01070/RR/NCRR NIH HHS/United States ; M01RR00037/RR/NCRR NIH HHS/United States ; M01RR001271/RR/NCRR NIH HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; U01 DP000245/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; UL1 RR026314/RR/NCRR NIH HHS/United States ; UL1 TR000077/TR/NCATS NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  29
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cf869f7aba17b0858973d4340f3fed649c61b85022da20d959880534b3b03315
• Download URL:
  https://stacks.cdc.gov/view/cdc/33817/cdc_33817_DS1.pdf
• File Type:
  [PDF - 193.44 KB ]