Observed Prevalence of Congenital Heart Defects From a Surveillance Study in China

Details

• Alternative Title:
  J Ultrasound Med
• Personal Author:
  Zhang, Yali ; Riehle-Colarusso, Tiffany ; Correa, Adolfo ; Li, Song ; Feng, Xinheng ; Gindler, Jacqueline ; Lin, Hui ; Webb, Catherine ; Li, Wei ; Trines, Jean ; Berry, Robert J. ; Yeung, Lorraine ; Luo, Ying ; Jiang, Meifang ; Chen, Hua ; Sun, Xiamei ; Li, Zhu
• Description:
  Objectives
  
  The purpose of this study was to estimate the prevalence of major and minor congenital heart defects among fetuses and neonates using sonography in a general population of 4 areas surrounding Shanghai, China.
  
  Methods
  
  Pregnant women were recruited between April 2004 and December 2005 in Jiaxing City, Suzhou City, Changshu County, and Haining County. All participants could have 3 sonographic examinations performed by specially trained physicians regardless of medical indication: a fetal sonographic screen and fetal echocardiography between 20 and 28 weeks’ gestation and neonatal echocardiography. Diagnoses of congenital heart defects were made on the basis of review of all available scans by an international group of experts in pediatric cardiology. Prevalence rates were calculated per 1000 births.
  
  Results
  
  Among 4006 scanned fetuses and neonates, there were 75 congenital heart defects, including 12 major defects. The observed prevalence for all congenital heart defects was 18.7 (95% confidence interval, 14.8–23.5) per 1000 births, and the prevalence for major defects was 3.0 (95% confidence interval, 1.6–5.2) per 1000 births. The most common defects were ventricular septal defects (n = 47 [62.7%]), atrial septal defects (n = 14 [18.7%]), tetralogy of Fallot (n = 4 [5.3%]), and hypoplastic left heart syndrome (n = 3 [4.0%]).
  
  Conclusions
  
  The prevalence of all congenital heart defects in the 4 areas of China studied was higher than that reported in other countries, with ventricular septal defects being the most frequent defects. Our data likely reflect a better estimate of the total prevalence of congenital heart defects in China than reported previously.
  
  
• Subjects:
  Chi-Square Distribution Echocardiography Female Heart Defects, Congenital Humans Infant, Newborn Population Surveillance Pregnancy Prevalence Prospective Studies Ultrasonography, Prenatal

  More +
• Source:
  J Ultrasound Med. 2011; 30(7):989-995
• Pubmed ID:
  21705732
• Pubmed Central ID:
  PMC4469985
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Place as Subject:
  China
• Volume:
  30
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:41b65d6262e6375ad92465c440f8c02097e9612685772e8c6a1719a8c0200fd4
• Download URL:
  https://stacks.cdc.gov/view/cdc/33782/cdc_33782_DS1.pdf
• File Type:
  [PDF - 192.38 KB ]