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Maternal Cigarette Smoking and Congenital Heart Defects
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  1. Maternal DNA hypomethylation and congenital heart defects
    Personal Author:
    Chowdhury, Shimul; Cleves, Mario A.; MacLeod, Stewart L.; James, S. Jill; Zhao, Weizhi; Hobbs, Charlotte A.;
    Published:
    Jan 19 2011
    Source:
    Birth Defects Res A Clin Mol Teratol. 91(2):69-76.
    Description:
    Background : Congenital heart defects (CHDs) are among the most prevalent and serious of birth defects. Multiple maternal factors are thought to contribute to CHD development including folate intake. Maternal DNA methylation, which is dependent on fo...
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  2. Maternal Periconceptional Exposure to Cigarette Smoking and Congenital Limb Deficiencies
    Personal Author:
    Caspers, Kristin M.; Romitti, Paul A.; Lin, Shao; Olney, Richard S.; Holmes, Lewis B.; Werler, Martha M.;
    Published:
    Jul 31 2013
    Source:
    Paediatr Perinat Epidemiol. 2013; 27(6):509-520.
    Description:
    Background : Congenital limb deficiencies (LD)s are characterised by the failure or disruption in formation of limbs or digits. Epidemiological research on maternal exposure to cigarette smoke and LDs is inconclusive. : Methods : Data from the Nation...
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  3. Associations between maternal genotypes and metabolites implicated in congenital heart defects
    Personal Author:
    Chowdhury, Shimul; Hobbs, Charlotte A.; MacLeod, Stewart L.; Cleves, Mario A.; Melnyk, Stepan; James, S. Jill; Hu, Ping; Erickson, Stephen W.;
    Published:
    Sep 27 2012
    Source:
    Mol Genet Metab. 2012; 107(3):596-604.
    Description:
    Background : The development of non-syndromic congenital heart defects (CHDs) involves a complex interplay of genetics, metabolism, and lifestyle. Previous studies have implicated maternal single nucleotide polymorphisms (SNPs) and altered metabolism...
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  4. Maternal Genome-Wide DNA Methylation Patterns and Congenital Heart Defects
    Personal Author:
    Chowdhury, Shimul; Erickson, Stephen W.; MacLeod, Stewart L.; Cleves, Mario A.; Hu, Ping; Karim, Mohammad A.; Hobbs, Charlotte A.;
    Published:
    Jan 24 2011
    Source:
    PLoS One. 6(1).
    Description:
    The majority of congenital heart defects (CHDs) are thought to result from the interaction between multiple genetic, epigenetic, environmental, and lifestyle factors. Epigenetic mechanisms are attractive targets in the study of complex diseases becau...
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  5. A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects
    Personal Author:
    Li, Ming; Li, Jingyun; Wei, Changshuai; Lu, Qing; Tang, Xinyu; Erickson, Stephen W.; Macleod, Stewart L.; Hobbs, Charlotte A.;
    Corporate Author:
    National Birth Defects Prevention Study
    Published:
    Nov 27 2015
    Source:
    Ann Hum Genet. 80(1):20-31.
    Description:
    Congenital heart defects (CHDs) develop through a complex interplay between genetic variants, epigenetic modifications, and maternal environmental exposures. Genetic studies of CHDs have commonly tested single genetic variants for association with CH...
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    Filetype[PDF - 340.59 KB]