No association of dietary fiber intake with inflammation or arterial stiffness in youth with type 1 diabetes

Details

• Alternative Title:
  J Diabetes Complications
• Personal Author:
  Jaacks, Lindsay M. ; Crandell, Jamie ; Liese, Angela D. ; Lamichhane, Archana P. ; Bell, Ronny A. ; Dabelea, Dana ; D'Agostino, Ralph B. ; Dolan, Lawrence M. ; Marcovina, Santica ; Reynolds, Kristi ; Shah, Amy S. ; Urbina, Elaine M. ; Wadwa, R. Paul ; Mayer-Davis, Elizabeth J.
• Description:
  Aim
  
  To examine the association of dietary fiber intake with inflammation and arterial stiffness among youth with type 1 diabetes (T1D) in the US.
  
  Methods
  
  Data are from youth ≥ 10 years old with clinically diagnosed T1D for ≥ 3 months and ≥ 1 positive diabetes autoantibody in the SEARCH for Diabetes in Youth Study. Fiber intake was assessed by food frequency questionnaire with measurement error (ME) accounted for by structural sub-models derived using additional 24-hour dietary recall data in a calibration sample and the respective exposure-disease model covariates. Markers of inflammation, measured at baseline, included IL-6 (n=1405), CRP (n=1387), and fibrinogen (n=1340); markers of arterial stiffness, measured approximately 19 months post-baseline, were available in a subset of participants and included augmentation index (n=180), pulse wave velocity (n=184), and brachial distensibility (n=177).
  
  Results
  
  Mean (SD) T1D duration was 47.9 (43.2) months; 12.5% of participants were obese. Mean (SD) ME-adjusted fiber intake was 15 (2.8) g/day. In multivariable analyses, fiber intake was not associated with inflammation or arterial stiffness.
  
  Conclusion
  
  Among youth with T1D, fiber intake does not meet recommendations and is not associated with measures of systemic inflammation or vascular stiffness. Further research is needed to evaluate whether fiber is associated with these outcomes in older individuals with T1D or among individuals with higher intakes than those observed in the present study.
  
  
• Subjects:
  Adolescent Age Factors Biomarkers Child Cohort Studies Diabetes Mellitus, Type 1 Dietary Fiber Female Fibrinogen Humans Inflammation Linear Models Male Pulse Wave Analysis Retrospective Studies Vascular Stiffness

  More +
• Source:
  J Diabetes Complications. 2014; 28(3):305-310.
• Pubmed ID:
  24613131
• Pubmed Central ID:
  PMC4011131
• Document Type:
  Journal Article
• Funding:
  00097/PHS HHS/United States ; 1U18DP002709/DP/NCCDPHP CDC HHS/United States ; 1UL1RR026314-01/RR/NCRR NIH HHS/United States ; 200-2010-35171/PHS HHS/United States ; DP-05-069/DP/NCCDPHP CDC HHS/United States ; DP-10-001/DP/NCCDPHP CDC HHS/United States ; K23 HL118132/HL/NHLBI NIH HHS/United States ; M01 RR00069/RR/NCRR NIH HHS/United States ; M01RR00037/RR/NCRR NIH HHS/United States ; P30 DK57516/DK/NIDDK NIH HHS/United States ; R01 DK 077949/DK/NIDDK NIH HHS/United States ; R01 DK 078542-01A2/DK/NIDDK NIH HHS/United States ; R01 DK077949/DK/NIDDK NIH HHS/United States ; R01 DK078542/DK/NIDDK NIH HHS/United States ; R01 ES 019168/ES/NIEHS NIH HHS/United States ; R01 ES019168/ES/NIEHS NIH HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; U18DP000247-06A1/DP/NCCDPHP CDC HHS/United States ; U18DP002708-01/DP/NCCDPHP CDC HHS/United States ; U18DP002710-01/DP/NCCDPHP CDC HHS/United States ; U18DP002714/DP/NCCDPHP CDC HHS/United States ; U48/CCU419249/PHS HHS/United States ; U48/CCU519239/PHS HHS/United States ; U48/CCU819241-3/PHS HHS/United States ; U48/CCU919219/PHS HHS/United States ; U58/CCU019235-4/PHS HHS/United States ; UL1 RR029882/RR/NCRR NIH HHS/United States ; UL1 TR000077/TR/NCATS NIH HHS/United States ; UL1 TR001082/TR/NCATS NIH HHS/United States ; UL1RR029882/RR/NCRR NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  28
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:99341e1bc0946964e59f8b4136a7b277c3bc4741286d73c5bc23a8ced72772c8
• Download URL:
  https://stacks.cdc.gov/view/cdc/29950/cdc_29950_DS1.pdf
• File Type:
  [PDF - 301.27 KB ]