The latency-associated nuclear antigen, a multifunctional protein central to Kaposi’s sarcoma-associated herpesvirus latency

Ballestas, Mary E; Kaye, Kenneth M

doi:10.2217/fmb.11.137

i

The latency-associated nuclear antigen, a multifunctional protein central to Kaposi’s sarcoma-associated herpesvirus latency

Supporting Files

12 2011
By Ballestas, Mary E ; Kaye, Kenneth M

File Language:

English

Details

Alternative Title:

Future Microbiol
Personal Author:

Ballestas, Mary E ; Kaye, Kenneth M
Description:

Latency-associated nuclear antigen (LANA) is encoded by the Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 73. LANA is expressed during latent KSHV infection of cells, including tumor cells, such as primary effusion lymphoma, KS and multicentric Castleman's disease. Latently infected cells have multiple extrachromosomal copies of covalently closed circular KSHV genomes (episomes) that are stably maintained in proliferating cells. LANA's best characterized function is that of mediating episome persistence. It does so by binding terminal repeat sequences to the chromosomal matrix, thus ensuring episome replication with each cell division and efficient DNA segregation to daughter nuclei after mitosis. To achieve these functions, LANA associates with different host cell proteins, including chromatin-associated proteins and proteins involved in DNA replication. In addition to episome maintenance, LANA has transcriptional regulatory effects and affects cell growth. LANA exerts these functions through interactions with different cell proteins.
Subjects:

AIDS Antigens, Viral Article Cell Division Chromosome Segregation DNA, Viral DNA Replication Herpesvirus 8, Human HIV Host-Pathogen Interactions Human Herpesvirus 8 Humans Kaposi’s Sarcoma Lymphoma Nuclear Proteins Plasmids Viral Latency Virulence Factors Virus Latency Virus Replication
Source:

Future Microbiol. 2011; 6(12)
Pubmed ID:

22122438
Pubmed Central ID:

PMC3857968
Document Type:

Journal Article
Funding:

P30 NS047466/NS/NINDS NIH HHSUnited States/ ; P30AR050498/AR/NIAMS NIH HHSUnited States/ ; PR093491/PR/OCPHP CDC HHSUnited States/ ; R01 CA082036/CA/NCI NIH HHSUnited States/ ; P30NS047466/NS/NINDS NIH HHSUnited States/ ; R01 AR050498/AR/NIAMS NIH HHSUnited States/ ; CA082036/CA/NCI NIH HHSUnited States/
Volume:

6
Issue:

12
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:952fd49f92db1c0d1b59bec9b11bb8cc6e28de210366fa46f0378dcd1c415728
Download URL:

https://stacks.cdc.gov/view/cdc/33649/cdc_33649_DS1.pdf
File Type:

[PDF - 1.15 MB ]

File Language:

English

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