Details:

Alternative Title:
Neuroepidemiology
Personal Author:
Flaherty, Matthew L.; Kissela, Brett; Khoury, Jane C.; Alwell, Kathleen; Moomaw, Charles J.; ... More +
Flaherty, Matthew L.; Kissela, Brett; Khoury, Jane C.; Alwell, Kathleen; Moomaw, Charles J.; Woo, Daniel; Khatri, Pooja; Ferioli, Simona; Adeoye, Opeolu; Broderick, Joseph P.; Kleindorfer, Dawn; Less -
Description:
Background Population-based studies have estimated that ≈15% of ischemic strokes are caused by large vessel cerebrovascular disease. We determined the types of large vessel atherosclerosis responsible for ischemic strokes in a population-based stroke study. Methods Patients with first-ever or recurrent ischemic stroke in the Greater Cincinnati area were identified during 2005 at all local hospitals. Study physicians assigned ischemic stroke subtypes. Overall event rates and incidence rates for first-ever events were calculated and age, race, and sex-adjusted to the 2000 US population. Results There were 2204 ischemic strokes, including 365 strokes of large vessel subtype (16.6% of all ischemic strokes). Extracranial internal carotid artery stenosis was associated with 8.0% of all ischemic strokes, while extracranial internal carotid artery occlusion and intracranial atherosclerosis were each associated with 3.5% of strokes. The annual rate of first-ever and recurrent stroke attributed to extracranial internal carotid stenosis was 13.4 (11.4–15.4) per 100,000 persons. We conservatively estimate that ≈ 41,000 strokes may be attributed to extracranial internal carotid artery stenosis annually in the United States. Conclusions Large vessel atherosclerosis is an important cause of stroke, with extracranial internal carotid artery stenosis significantly more common than extracranial internal carotid artery occlusion or intracranial atherosclerotic disease.
Subject:
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Article
Carotid Stenosis
Female
Hospitalization
Humans
Male
Population Surveillance
Stroke

Source:
Neuroepidemiology. 40(1):36-41.;
Pubmed ID:
23075828
Pubmed Central ID:
PMC3626492
Document Type:
Journal Article;
Funding:
1U01NS069763/NS/NINDS NIH HHS/United States; 2P50NS044283/NS/NINDS NIH HHS/United States; 5R01NS0678/NS/NINDS NIH HHS/United States; 5U01NS062851/NS/NINDS NIH HHS/United States; 5U10NS058982/NS/NINDS NIH HHS/United States; ... More +
1U01NS069763/NS/NINDS NIH HHS/United States; 2P50NS044283/NS/NINDS NIH HHS/United States; 5R01NS0678/NS/NINDS NIH HHS/United States; 5U01NS062851/NS/NINDS NIH HHS/United States; 5U10NS058982/NS/NINDS NIH HHS/United States; 5UO1NS052220/NS/NINDS NIH HHS/United States; K23NS049463/NS/NINDS NIH HHS/United States; K23NS059843/NS/NINDS NIH HHS/United States; MM-0971-07/07/PHS HHS/United States; P50 NC 44283/PHS HHS/United States; P50 NS044283/NS/NINDS NIH HHS/United States; R-01-NS030678/NS/NINDS NIH HHS/United States; R01 AR055563/AR/NIAMS NIH HHS/United States; R01 AR056259/AR/NIAMS NIH HHS/United States; R01 DK68463/DK/NIDDK NIH HHS/United States; R01 ES015517/ES/NIEHS NIH HHS/United States; R01 NS 30678/NS/NINDS NIH HHS/United States; R01 NS030678/NS/NINDS NIH HHS/United States; R01N0S36695/PHS HHS/United States; R01ND039987/ND/ONDIEH CDC HHS/United States; R01NS030678/NS/NINDS NIH HHS/United States; R01NS036695/NS/NINDS NIH HHS/United States; R01NS039512/NS/NINDS NIH HHS/United States; R01NS042167/NS/NINDS NIH HHS/United States; R01NS044876/NS/NINDS NIH HHS/United States; R01NS052220/NS/NINDS NIH HHS/United States; R01NS069208/NS/NINDS NIH HHS/United States; R01NS30678/NS/NINDS NIH HHS/United States; R01NS39512/NS/NINDS NIH HHS/United States; R03CA142099/CA/NCI NIH HHS/United States; T32 NS047996/NS/NINDS NIH HHS/United States; U01 NS041588/NS/NINDS NIH HHS/United States; U01 NS058728/NS/NINDS NIH HHS/United States; U01NS052220/NS/NINDS NIH HHS/United States; U01NS056975/NS/NINDS NIH HHS/United States; U01NS069763/NS/NINDS NIH HHS/United States; UL1 RR026/RR/NCRR NIH HHS/United States; UL1 TR000077/TR/NCATS NIH HHS/United States; Less -
Place as Subject:
Ohio;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3c0688578d4c854ea5eb3518364a2605b13a0fac89a170d1926a2257753afc64
File Type:

Supporting Files

• 	NIHMS442996-supplement-01.pdf	pdf
  	nihms442996.nxml	bin

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