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Carotid Artery Stenosis as a Cause of Stroke
  • Published Date:
    Oct 11 2012
  • Source:
    Neuroepidemiology. 40(1):36-41.
Filetype[PDF - 292.07 KB]


Details:
  • Pubmed ID:
    23075828
  • Pubmed Central ID:
    PMC3626492
  • Description:
    Background

    Population-based studies have estimated that ≈15% of ischemic strokes are caused by large vessel cerebrovascular disease. We determined the types of large vessel atherosclerosis responsible for ischemic strokes in a population-based stroke study.

    Methods

    Patients with first-ever or recurrent ischemic stroke in the Greater Cincinnati area were identified during 2005 at all local hospitals. Study physicians assigned ischemic stroke subtypes. Overall event rates and incidence rates for first-ever events were calculated and age, race, and sex-adjusted to the 2000 US population.

    Results

    There were 2204 ischemic strokes, including 365 strokes of large vessel subtype (16.6% of all ischemic strokes). Extracranial internal carotid artery stenosis was associated with 8.0% of all ischemic strokes, while extracranial internal carotid artery occlusion and intracranial atherosclerosis were each associated with 3.5% of strokes. The annual rate of first-ever and recurrent stroke attributed to extracranial internal carotid stenosis was 13.4 (11.4–15.4) per 100,000 persons. We conservatively estimate that ≈ 41,000 strokes may be attributed to extracranial internal carotid artery stenosis annually in the United States.

    Conclusions

    Large vessel atherosclerosis is an important cause of stroke, with extracranial internal carotid artery stenosis significantly more common than extracranial internal carotid artery occlusion or intracranial atherosclerotic disease.

  • Document Type:
  • Collection(s):
  • Funding:
    1U01NS069763/NS/NINDS NIH HHS/United States
    2P50NS044283/NS/NINDS NIH HHS/United States
    5R01NS0678/NS/NINDS NIH HHS/United States
    5U01NS062851/NS/NINDS NIH HHS/United States
    5U10NS058982/NS/NINDS NIH HHS/United States
    5UO1NS052220/NS/NINDS NIH HHS/United States
    K23NS049463/NS/NINDS NIH HHS/United States
    K23NS059843/NS/NINDS NIH HHS/United States
    MM-0971-07/07/PHS HHS/United States
    P50 NC 44283/PHS HHS/United States
    P50 NS044283/NS/NINDS NIH HHS/United States
    R-01-NS030678/NS/NINDS NIH HHS/United States
    R01 AR055563/AR/NIAMS NIH HHS/United States
    R01 AR056259/AR/NIAMS NIH HHS/United States
    R01 DK68463/DK/NIDDK NIH HHS/United States
    R01 ES015517/ES/NIEHS NIH HHS/United States
    R01 NS 30678/NS/NINDS NIH HHS/United States
    R01 NS030678/NS/NINDS NIH HHS/United States
    R01N0S36695/PHS HHS/United States
    R01ND039987/ND/ONDIEH CDC HHS/United States
    R01NS030678/NS/NINDS NIH HHS/United States
    R01NS036695/NS/NINDS NIH HHS/United States
    R01NS039512/NS/NINDS NIH HHS/United States
    R01NS042167/NS/NINDS NIH HHS/United States
    R01NS044876/NS/NINDS NIH HHS/United States
    R01NS052220/NS/NINDS NIH HHS/United States
    R01NS069208/NS/NINDS NIH HHS/United States
    R01NS30678/NS/NINDS NIH HHS/United States
    R01NS39512/NS/NINDS NIH HHS/United States
    R03CA142099/CA/NCI NIH HHS/United States
    T32 NS047996/NS/NINDS NIH HHS/United States
    U01 NS041588/NS/NINDS NIH HHS/United States
    U01 NS058728/NS/NINDS NIH HHS/United States
    U01NS052220/NS/NINDS NIH HHS/United States
    U01NS056975/NS/NINDS NIH HHS/United States
    U01NS069763/NS/NINDS NIH HHS/United States
    UL1 RR026/RR/NCRR NIH HHS/United States
    UL1 TR000077/TR/NCATS NIH HHS/United States
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