Carotid Artery Stenosis as a Cause of Stroke

Flaherty, Matthew L.; Kissela, Brett; Khoury, Jane C.; Alwell, Kathleen; Moomaw, Charles J.; Woo, Daniel; Khatri, Pooja; Ferioli, Simona; Adeoye, Opeolu; Broderick, Joseph P.; Kleindorfer, Dawn

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Carotid Artery Stenosis as a Cause of Stroke

Published Date:

Oct 11 2012

Source:

Neuroepidemiology. 40(1):36-41.

Language:

English

[PDF-292.07 KB]

Details:

Alternative Title:

Neuroepidemiology

Personal Author:

Flaherty, Matthew L. ; Kissela, Brett ; Khoury, Jane C. ; Alwell, Kathleen ; Moomaw, Charles J. ; ... More ▼

Description:

Background

Population-based studies have estimated that ≈15% of ischemic strokes are caused by large vessel cerebrovascular disease. We determined the types of large vessel atherosclerosis responsible for ischemic strokes in a population-based stroke study.

Methods

Patients with first-ever or recurrent ischemic stroke in the Greater Cincinnati area were identified during 2005 at all local hospitals. Study physicians assigned ischemic stroke subtypes. Overall event rates and incidence rates for first-ever events were calculated and age, race, and sex-adjusted to the 2000 US population.

Results

There were 2204 ischemic strokes, including 365 strokes of large vessel subtype (16.6% of all ischemic strokes). Extracranial internal carotid artery stenosis was associated with 8.0% of all ischemic strokes, while extracranial internal carotid artery occlusion and intracranial atherosclerosis were each associated with 3.5% of strokes. The annual rate of first-ever and recurrent stroke attributed to extracranial internal carotid stenosis was 13.4 (11.4–15.4) per 100,000 persons. We conservatively estimate that ≈ 41,000 strokes may be attributed to extracranial internal carotid artery stenosis annually in the United States.

Conclusions

Large vessel atherosclerosis is an important cause of stroke, with extracranial internal carotid artery stenosis significantly more common than extracranial internal carotid artery occlusion or intracranial atherosclerotic disease.

Subject:

[+]

Pubmed ID:

23075828

Pubmed Central ID:

PMC3626492

Document Type:

Journal Article

Funding:

1U01NS069763/NS/NINDS NIH HHS/United States ; 2P50NS044283/NS/NINDS NIH HHS/United States ; 5R01NS0678/NS/NINDS NIH HHS/United States ; 5U01NS062851/NS/NINDS NIH HHS/United States ; 5U10NS058982/NS/NINDS NIH HHS/United States ; ... More ▼

Place as Subject:

Ohio

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	NIHMS442996-supplement-01.pdf	application/pdf
	nihms442996.nxml	application/octet-stream

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