Carotid Artery Stenosis as a Cause of Stroke

Details

• Alternative Title:
  Neuroepidemiology
• Personal Author:
  Flaherty, Matthew L. ; Kissela, Brett ; Khoury, Jane C. ; Alwell, Kathleen ; Moomaw, Charles J. ; Woo, Daniel ; Khatri, Pooja ; Ferioli, Simona ; Adeoye, Opeolu ; Broderick, Joseph P. ; Kleindorfer, Dawn
• Description:
  Background
  
  Population-based studies have estimated that ≈15% of ischemic strokes are caused by large vessel cerebrovascular disease. We determined the types of large vessel atherosclerosis responsible for ischemic strokes in a population-based stroke study.
  
  Methods
  
  Patients with first-ever or recurrent ischemic stroke in the Greater Cincinnati area were identified during 2005 at all local hospitals. Study physicians assigned ischemic stroke subtypes. Overall event rates and incidence rates for first-ever events were calculated and age, race, and sex-adjusted to the 2000 US population.
  
  Results
  
  There were 2204 ischemic strokes, including 365 strokes of large vessel subtype (16.6% of all ischemic strokes). Extracranial internal carotid artery stenosis was associated with 8.0% of all ischemic strokes, while extracranial internal carotid artery occlusion and intracranial atherosclerosis were each associated with 3.5% of strokes. The annual rate of first-ever and recurrent stroke attributed to extracranial internal carotid stenosis was 13.4 (11.4–15.4) per 100,000 persons. We conservatively estimate that ≈ 41,000 strokes may be attributed to extracranial internal carotid artery stenosis annually in the United States.
  
  Conclusions
  
  Large vessel atherosclerosis is an important cause of stroke, with extracranial internal carotid artery stenosis significantly more common than extracranial internal carotid artery occlusion or intracranial atherosclerotic disease.
  
  
• Subjects:
  Carotid Stenosis Female Hospitalization Humans Male Ohio Population Surveillance Stroke
• Keywords:
  Carotid Atherosclerosis Carotid Occlusion Carotid Stenosis Epidemiology Intracranial Atherosclerosis Stroke Stroke Etiology
• Source:
  Neuroepidemiology. 40(1):36-41
• Pubmed ID:
  23075828
• Pubmed Central ID:
  PMC3626492
• Document Type:
  Journal Article
• Funding:
  R01NS042167/NS/NINDS NIH HHSUnited States/ ; U01 NS062851/NS/NINDS NIH HHSUnited States/ ; 5U01NS062851/NS/NINDS NIH HHSUnited States/ ; R-01-NS030678/NS/NINDS NIH HHSUnited States/ ; U01 NS044876/NS/NINDS NIH HHSUnited States/ ; R01NS044876/NS/NINDS NIH HHSUnited States/ ; U01NS052220/NS/NINDS NIH HHSUnited States/ ; U01 NS052220/NS/NINDS NIH HHSUnited States/ ; U01 NS036695/NS/NINDS NIH HHSUnited States/ ; U01NS069763/NS/NINDS NIH HHSUnited States/ ; K23 NS049463/NS/NINDS NIH HHSUnited States/ ; R01ND039987/ND/ONDIEH CDC HHSUnited States/ ; 5UO1NS052220/NS/NINDS NIH HHSUnited States/ ; R01NS036695/NS/NINDS NIH HHSUnited States/ ; U01 NS058728/NS/NINDS NIH HHSUnited States/ ; R01 NS030678/NS/NINDS NIH HHSUnited States/ ; 5U10NS058982/NS/NINDS NIH HHSUnited States/ ; K23NS059843/NS/NINDS NIH HHSUnited States/ ; T32 NS047996/NS/NINDS NIH HHSUnited States/ ; R01 NS039512/NS/NINDS NIH HHSUnited States/ ; 5R01NS0678/NS/NINDS NIH HHSUnited States/ ; U01 NS056975/NS/NINDS NIH HHSUnited States/ ; 2P50NS044283/NS/NINDS NIH HHSUnited States/ ; R01N0S36695/PHS HHSUnited States/ ; P50 NS044283/NS/NINDS NIH HHSUnited States/ ; R01 DK68463/DK/NIDDK NIH HHSUnited States/ ; K23 NS059843/NS/NINDS NIH HHSUnited States/ ; 1U01NS069763/NS/NINDS NIH HHSUnited States/ ; R01 NS 30678/NS/NINDS NIH HHSUnited States/ ; R01NS030678/NS/NINDS NIH HHSUnited States/ ; R01 DK068463/DK/NIDDK NIH HHSUnited States/ ; U01 NS042167/NS/NINDS NIH HHSUnited States/ ; U01NS056975/NS/NINDS NIH HHSUnited States/ ; MM-0971-07/07/PHS HHSUnited States/ ; R01 AR055563/AR/NIAMS NIH HHSUnited States/ ; U01 NS069763/NS/NINDS NIH HHSUnited States/ ; U01 NS069208/NS/NINDS NIH HHSUnited States/ ; R01NS30678/NS/NINDS NIH HHSUnited States/ ; U10 NS058982/NS/NINDS NIH HHSUnited States/ ; U01 NS041588/NS/NINDS NIH HHSUnited States/ ; R01NS052220/NS/NINDS NIH HHSUnited States/ ; R03 CA142099/CA/NCI NIH HHSUnited States/ ; K23NS049463/NS/NINDS NIH HHSUnited States/ ; P50 NC 44283/PHS HHSUnited States/ ; R01NS069208/NS/NINDS NIH HHSUnited States/ ; R01 NS036695/NS/NINDS NIH HHSUnited States/ ; UL1 TR000077/TR/NCATS NIH HHSUnited States/ ; R03CA142099/CA/NCI NIH HHSUnited States/ ; R01NS39512/NS/NINDS NIH HHSUnited States/ ; R01 AR056259/AR/NIAMS NIH HHSUnited States/ ; UL1 RR026/RR/NCRR NIH HHSUnited States/ ; R01NS039512/NS/NINDS NIH HHSUnited States/ ; R01 ES015517/ES/NIEHS NIH HHSUnited States/
• Volume:
  40
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c386f89d7370e79aff161988a844a2d58cf49cd4a382a4af339d92462df5b05cbc804a6b51ca441d42115c4c1649ce847490528e710e5252c1e6108cfc88ffa6
• Download URL:
  https://stacks.cdc.gov/view/cdc/33541/cdc_33541_DS1.pdf
• File Type:
  [PDF - 292.07 KB ]