Label-Free Polypeptide-Based Enzyme Detection Using a Graphene-Nanoparticle Hybrid Sensor

Myung, Sung; Yin, Perry T.; Kim, Cheoljin; Park, Jaesung; Solanki, Aniruddh; Reyes, Pavel Ivanoff; Lu, Yicheng; Kim, Kwang S.; Lee, Ki-Bum

doi:10.1002/adma.201202961

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Label-Free Polypeptide-Based Enzyme Detection Using a Graphene-Nanoparticle Hybrid Sensor

Published Date:

Sep 07 2012

Publisher's site:

http://dx.doi.org/10.1002/adma.201202961 New Site Icon

Source:

Adv Mater. 2012; 24(45):6081-6087.

[PDF-2.51 MB]

Details:

Personal Authors:

Myung, Sung ; Yin, Perry T. ; Kim, Cheoljin ; Park, Jaesung ; Solanki, Aniruddh ; ... More ▼

Keywords:

[+]

Pubmed ID:

22961629

Pubmed Central ID:

PMC3626444

Description:

A graphene-nanoparticle (NP) hybrid biosensor that utilizes an electrical hysteresis change to detect the enzymatic activity and concentration of Carboxypeptidase B was developed. The results indicate that the novel graphene-NP hybrid biosensor, utilizing electrical hysteresis, has the ability to detect concentrations of targeted enzyme on the micromolar scale. Furthermore, to the knowledge of the authors, this is the first demonstration of a graphene-based biosensor that utilizes a hysteresis change resulting from metallic NPs assembled on a graphene surface.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1DP20D006462-01/DP/NCCDPHP CDC HHS/United States
DP2 OD006462/OD/NIH HHS/United States
T32 GM008339/GM/NIGMS NIH HHS/United States

Supporting Files:

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