Label-Free Polypeptide-Based Enzyme Detection Using a Graphene-Nanoparticle Hybrid Sensor

Myung, Sung; Yin, Perry T.; Kim, Cheoljin; Park, Jaesung; Solanki, Aniruddh; Reyes, Pavel Ivanoff; Lu, Yicheng; Kim, Kwang S.; Lee, Ki-Bum

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Label-Free Polypeptide-Based Enzyme Detection Using a Graphene-Nanoparticle Hybrid Sensor

Published Date:

September 07 2012

Source:

Adv Mater. 2012; 24(45):6081-6087

Language:

English

[PDF-2.51 MB]

Details:

Alternative Title:

Adv Mater

Personal Author:

Myung, Sung ; Yin, Perry T. ; Kim, Cheoljin ; Park, Jaesung ; Solanki, Aniruddh ; ... More ▼

Description:

A graphene-nanoparticle (NP) hybrid biosensor that utilizes an electrical hysteresis change to detect the enzymatic activity and concentration of Carboxypeptidase B was developed. The results indicate that the novel graphene-NP hybrid biosensor, utilizing electrical hysteresis, has the ability to detect concentrations of targeted enzyme on the micromolar scale. Furthermore, to the knowledge of the authors, this is the first demonstration of a graphene-based biosensor that utilizes a hysteresis change resulting from metallic NPs assembled on a graphene surface.

Subject:

[+]

Pubmed ID:

22961629

Pubmed Central ID:

PMC3626444

Document Type:

Journal Article

Funding:

DP2 OD006462/OD/NIH HHS/United States ; T32 GM008339/GM/NIGMS NIH HHS/United States ; 1DP20D006462-01/DP/NCCDPHP CDC HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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