23275423

PMC3615120

Purpose

The goal of this study was to investigate the etiologic basis for the association between deficits in phonological memory (PM) and vocabulary in school-age children.

Method

Children with deficits in PM or vocabulary were identified within the International Longitudinal Twin Study (ILTS). The ILTS includes 1,045 twin pairs from the United States, Australia, and Scandinavia aged 5 to 8 years. We applied the DeFries-Fulker regression method to determine whether problems in PM and vocabulary tend to co-occur because of overlapping genes, overlapping environmental risk factors, or both.

Results

Among children with isolated PM deficits, we found significant bivariate heritability of PM and vocabulary weaknesses both within and across time. However, when probands were selected for a vocabulary deficit, there was no evidence for bivariate heritability. In this case, the PM-vocabulary relationship appeared to owe to common shared environmental experiences.

Conclusions

The findings are consistent with previous research on the heritability of specific language impairment and suggest that there are etiologic subgroups of children with poor vocabulary for different reasons, one more influenced by genes and another more influenced by environment.

CDC Public Access

R01 HD068728/HD/NICHD NIH HHS/United States
P50 HD027802/HD/NICHD NIH HHS/United States
DP0770805/DP/NCCDPHP CDC HHS/United States
R01 HD038526/HD/NICHD NIH HHS/United States
DP0663498/DP/NCCDPHP CDC HHS/United States
R01 HD049027/HD/NICHD NIH HHS/United States